Chondroitin Sulfate Proteoglycans: A Key Substance for Central Nervous System Injury Repair

  • Atsuhiko Oohira


Research on proteoglycans originally advanced using connective tissues such as cartilage as a source. In the 1990s, it was found that multiple species of proteoglycans, both heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs), existed in the central nervous system (CNS). Of these proteoglycans, some such as neurocan, phosphacan/RPTPβ, and neuroglycan C are predominantly expressed in the CNS. Since the CNS contains a very small amount of fibrous collagen, if any, proteoglycans are the major glycoconjugate in the microenvironment of neural cells.


Neural Stem Cell Lesion Site Injury Repair Axon Regeneration Glial Scar 
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© Springer 2008

Authors and Affiliations

  • Atsuhiko Oohira
    • 1
  1. 1.Research Complex for the Medicine FrontiersAichi Medical UniversityAichiJapan

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