Chondroitin Sulfate Proteoglycans and Neuronal Network Formation

  • Nobuaki Maeda


Chondroitin sulfate proteoglycans play important roles in the development of the nervous system including neuronal migration, neurite extension, and synapse formation (Maeda 2007). The physiological functions of chondroitin sulfate proteoglycans in the developing nervous system can be investigated using various in vitro culture systems as described below.


Chondroitin Sulfate Sodium Selenite Neurite Extension Chondroitin Sulfate Proteoglycan Organotypic Slice Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Maeda N (2007) A chondroitin sulfate proteoglycan, PTPζ/phosphacan, and neuronal network formation. In: Weiss ML (ed) Neuronal network research horizons. Nova Science Pub, New York, pp 179–203Google Scholar
  2. Maeda N, Noda M (1996) 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons. Development 122:647–658PubMedGoogle Scholar
  3. Maeda N, Noda M (1998) Involvement of receptor-like protein tyrosine phosphatase ζ/RPTPβ and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J Cell Biol 142:203–216PubMedCrossRefGoogle Scholar
  4. Qi M, Ikematsu S, Maeda N, Ichihara-Tanaka K, Sakuma S, Noda M, Muramatsu T, Kadomatsu K (2001) Haptotactic migration induced by midkine.-Involvement of protein-tyrosine phosphatase ζ, mitogenactivated protein kinase, and phosphatidylinositol 3-kinase. J Biol Chem 276:15868–15875PubMedGoogle Scholar
  5. Tanaka M, Maeda N, Noda M, Marunouchi T (2003) A chondroitin sulfate proteoglycan PTPζ/RPTPβ regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum. J Neurosci 23:2804–2814PubMedGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Nobuaki Maeda
    • 1
  1. 1.Department of Developmental NeuroscienceTokyo Metropolitan Institute for NeuroscienceFuchu, TokyoJapan

Personalised recommendations