Functional Roles of the HNK-1 Carbohydrate and Polysialic Acid in the Nervous System

  • Yasuhiko Kizuka
  • Shogo Oka


In the nervous system, many types of cells recognize each other to form a precise neural network, whereas these cells are morphologically and functionally different. The development and maintenance of this complicated but accurate network involves many molecules. Among them, cell adhesion molecules (CAMs) are considered to play important roles in these processes. On these CAMs in the nervous system, unique carbohydrate epitopes are known to be expressed such as HNK-1 (Human Natural Killer-1, also called CD57) and PSA (polysialic acid), which are rarely found in other organs or tissues. Recently, it was revealed that these unique carbohydrates are involved in the formation and maintenance of neural network.


Sialic Acid Synaptic Plasticity Null Mouse Neural Crest Cell Neural Cell Adhesion Molecule 
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  1. Senn C, Kutsche M, Saghatelyan A, Bosl MR, Lohler J, Bartsch U, Morellini F, Schachner M (2002) Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. Mol Cell Neurosci 20:712–729PubMedCrossRefGoogle Scholar
  2. Weinhold B, Seidenfaden R, Rockle I, Muhlenhoff M, Schertzinger F, Conzelmann S, Marth JD, Gerardy-Schahn R, Hildebrandt H (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem 280:42971–42977PubMedCrossRefGoogle Scholar
  3. Yamamoto S, Oka S, Inoue M, Shimuta M, Manabe T, Takahashi H, Miyamoto M, Asano M, Sakagami J, Sudo K, Iwakura Y, Ono K, Kawasaki T (2002) Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem 277:27227–27231PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Yasuhiko Kizuka
    • 1
  • Shogo Oka
    • 2
  1. 1.Department of Biological Chemistry, Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan
  2. 2.Department of Biological Chemistry, School of Health Sciences, Faculty of MedicineKyoto UniversityKyotoJapan

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