UDP-N-Acetyl-d-Galactosamine:polypeptide N-Acetylgalactosaminyltransferases (ppGaNTases, pp-GalNAc-Ts, EC 184.108.40.206)
UDP-N-acetyl-d-galactosamine:polypeptide N-acetylgalactosaminyltransferases (ppGaNTases) are the glycosyltransferases that transfer GalNAc from the sugar donor UDP-GalNAc to serine and threonine residues on polypeptides (White et al. 1995; Ten Hagen et al. 2003). This is the initial step of mucin-type linkages (GalNAcα1-O-Ser/Thr); hence, this enzyme family is involved in the first step in mucin biosynthesis.
KeywordsThreonine Residue Acceptor Substrate Lectin Domain Protein Expression Vector Peptide Sequencer Analysis
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