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Carbohydrate Recognition by Cytokines and Its Relevance to Their Physiological Activities

  • Keiko Fukushima
  • Katsuko Yamashita

Abstract

Cytokines regulate the immune response, inflammation, cell proliferation and differentiation as mediators of the regulatory network among lymphoid cells, hematopoietic cells, and endothelial cells. Many signal transduction mechanisms are evoked after cytokines bind to their respective receptors. Most cytokine receptors consist of several specific receptor subunits. These subunits form high-affinity complexes with their respective cytokines, which then induce various physiological effects. The formation of cytokine-receptor complexes cannot be explained by the simple interaction between a cytokine and its receptor. Lectin-like characteristics of cytokines may provide an insight into their multiple functions, although their physiological significance has not generally been elucidated (Yamashita and Fukushima 2007).

Keywords

Chondroitin Sulfate Sodium Chlorate Hexuronic Acid Respective Cytokine Phosphate Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Fukushima K, Hara-Kuge S, Ideo H, Yamashita K (2001) Carbohydrate recognition site of interleukin-2 in relation to cell proliferation. J Biol Chem 276:31202–31208PubMedCrossRefGoogle Scholar
  2. Fukushima K, Ikehara Y, Yamashita K (2005) Functional role played by the GPI-anchor glycan of CD48 in IL-18-induced IFN-gamma production. J Biol Chem 280:18056–18062PubMedCrossRefGoogle Scholar
  3. Yamashita K, Fukushima K (2007) In: Kamerling JP (ed) Comprehensive glycoscience. Elsevier, Amsterdam, pp 337–363Google Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Keiko Fukushima
    • 1
  • Katsuko Yamashita
    • 1
  1. 1.Innovative Research InitiativesTokyo Institute of TechnologyYokohamaJapan

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