Carbohydrate Ligands for Selectins in Immune Cell Trafficking

  • Reiji Kannagi
  • Katsuyuki Ohmori


The first step of leukocyte extravasation is adhesion of leukocytes to endothelial cells mediated by selectins and their carbohydrate ligands (Fig. 1). This cell adhesion system tethers leukocytes in the bloodstream to endothelial walls, and this in turn triggers the action of chemokines that are expressed on the endothelial surface. Signal transduction through leukocyte chemokine receptors activates leukocyte integrins, which lead to extravasation of leukocytes.


Hyaluronic Acid High Endothelial Venule Carbohydrate Determinant Secondary Lymphoid Tissue Leukocyte Extravasation 
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© Springer 2008

Authors and Affiliations

  • Reiji Kannagi
    • 1
  • Katsuyuki Ohmori
    • 2
  1. 1.Department of Molecular PathologyAichi Cancer CenterNagoyaJapan
  2. 2.Department of Clinical PathologyKyoto University School of MedicineKyotoJapan

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