Carbohydrate Ligands for Selectins in Immune Cell Trafficking
The first step of leukocyte extravasation is adhesion of leukocytes to endothelial cells mediated by selectins and their carbohydrate ligands (Fig. 1). This cell adhesion system tethers leukocytes in the bloodstream to endothelial walls, and this in turn triggers the action of chemokines that are expressed on the endothelial surface. Signal transduction through leukocyte chemokine receptors activates leukocyte integrins, which lead to extravasation of leukocytes.
KeywordsHyaluronic Acid High Endothelial Venule Carbohydrate Determinant Secondary Lymphoid Tissue Leukocyte Extravasation
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- Kannagi R (2001) Transcriptional regulation of expression of carbohydrate ligands for cell adhesion molecules in the selectin family. In: Wu AM (ed) Advances in experimental medicine and biology, vol 491. Molecular Immunology of Complex Carbohydrates II. Plenum, New York, pp 267–278Google Scholar
- Mitsuoka C, Sawada-Kasugai M, Ando-Furui K, Izawa M, Nakanishi H, Nakamura S, Ishida H, Kiso M, Kannagi R (1998) Identification of a major carbohydrate capping group of the l-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis x. J Biol Chem 273:11225–11233PubMedCrossRefGoogle Scholar