Siglec Family

  • Takashi Angata


Siglec family is the largest-known group of vertebrate lectins that recognize sialylated glycans (Fig. 1A; Varki and Angata 2006). Humans have more than 10 Siglecs, most of which are expressed on the cells in the immune system. Most Siglecs also interact with proteins involved in intracellular signaling. Different species have different set of Siglecs (Angata 2006), and the glycan binding specificity of each Siglec differs markedly (Blixt et al. 2003). Glycan recognition is essential for Siglec function (Poe et al. 2004). Therefore, it is essential to know the glycan-binding specificity of each Siglec to understand its higher-order function.


Phosphatase Substrate Glycan Binding ELISA Buffer Glycan Recognition Siglec Family 
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  1. Angata T (2006) Molecular diversity and evolution of the Siglec family of cell-surface lectins. Mol Divers 10:555–566PubMedCrossRefGoogle Scholar
  2. Blixt O, Collins BE, van den Nieuwenhof IM, Crocker PR, Paulson JC (2003) Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein. J Biol Chem 278:31007–31019PubMedCrossRefGoogle Scholar
  3. Poe JC, Fujimoto Y, Hasegawa M, Haas KM, Miller AS, Sanford IG, Bock CB, Fujimoto M, Tedder TF (2004) CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligandindependent mechanisms. Nat Immunol 5:1078–1087PubMedCrossRefGoogle Scholar
  4. Varki A, Angata T (2006) Siglecs-the major subfamily of I-type lectins. Glycobiology 16:1R–27RPubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Takashi Angata
    • 1
  1. 1.Research Center for Medical GlycoscienceNational Institute of Advanced Industrial Science and Technology (AIST)Tsukuba, IbarakiJapan

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