Sulfotransferases Involved in Sulfation of Glycosaminoglycans
Sulfated glycosaminoglycans are linear polysaccharides composed of various types of repeating disaccharide units. Combination of different types of disaccharide units generates huge structural diversity in each glycosaminoglycan chain. Glycosaminoglycans have been reported to be involved in various biological phenomena through specific interactions with various proteins. These interactions are mediated by specific structural domain of glycosaminoglycans (Bulow and Hobert 2006; Kimata et al. 2007). Each sulfotransferase involved in the synthesis of glycosaminoglycans has strict acceptor specificity, and plays crucial roles in the formation of the specific structural domain (Habuchi 2000; Kusche-Gullberg and Kjellen 2003; (eds)). Almost all glycosaminoglycan sulfotransferases have been cloned so far, and the substrate specificity of each sulfotransferase has been studied. In Table 1, glycosaminoglycan sulfotransferases so far cloned and characterized are shown.
KeywordsHeparan Sulfate Sulfated Glycosaminoglycan Corneal Dystrophy GlcNAc Residue Repeat Disaccharide Unit
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