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Sulfotransferases Involved in Sulfation of Glycosaminoglycans

  • Osami Habuchi

Abstract

Sulfated glycosaminoglycans are linear polysaccharides composed of various types of repeating disaccharide units. Combination of different types of disaccharide units generates huge structural diversity in each glycosaminoglycan chain. Glycosaminoglycans have been reported to be involved in various biological phenomena through specific interactions with various proteins. These interactions are mediated by specific structural domain of glycosaminoglycans (Bulow and Hobert 2006; Kimata et al. 2007). Each sulfotransferase involved in the synthesis of glycosaminoglycans has strict acceptor specificity, and plays crucial roles in the formation of the specific structural domain (Habuchi 2000; Kusche-Gullberg and Kjellen 2003; (eds)). Almost all glycosaminoglycan sulfotransferases have been cloned so far, and the substrate specificity of each sulfotransferase has been studied. In Table 1, glycosaminoglycan sulfotransferases so far cloned and characterized are shown.

Keywords

Heparan Sulfate Sulfated Glycosaminoglycan Corneal Dystrophy GlcNAc Residue Repeat Disaccharide Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bulow HE, Hobert O (2006) The molecular diversity of glycosaminoglycans shapes animal development. Annu Rev Cell Dev Biol 22:375–407PubMedCrossRefGoogle Scholar
  2. Habuchi O (2000) Diversity and functions of glycosaminoglycan sulfotransferases. Biochim Biophys Acta 1474:115–127PubMedGoogle Scholar
  3. Kimata K, Habuchi O, Habuchi H, Watanabe H (2007) Knockout mice and proteoglycans. In: Kamerling JP et al (eds) Comprehensive glycoscience, vol 3, Chap 4.10. Elsevier, Amsterdam, pp 159–191Google Scholar
  4. Kusche-Gullberg M, Kjellen L (2003) Sulfotransferases in glycosaminoglycan biosynthesis. Curr Opin Struct Biol 13:605–611PubMedCrossRefGoogle Scholar
  5. Taniguchi N, Honke K, Fukuda M (eds) (2001) Sulfotransferases. In: Handbook of glycosyltransferases and related genes. Springer, Tokyo, pp 413–508Google Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Osami Habuchi
    • 1
  1. 1.Department of ChemistryAichi University of EducationIgaya-cho, KariyaJapan

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