N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) transfers a sulfate group from PAPS to an N-acetylglucosamine residue, which is usually located at the non-reducing end of glycoconjugates. It is important to note that sulfation proceeds the elongation of the glycan chain. This enzyme is involved in the synthesis of keratan sulfate and sialyl 6-sulfo Lewis X, which is present on the luminal surface of the high endothelial venule (HEV) of lymph nodes. So far, five isozymes of GlcNAc6ST have been identified in humans (Table 1). They share about 30% sequence identity, and have the configuration of type II transmembrane proteins, a feature typical of Golgi-located enzymes.
KeywordsMucinous Adenocarcinoma Keratan Sulfate High Endothelial Venule Corneal Dystrophy Rolling Velocity
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