• Kenji Uchimura
  • Takashi Muramatsu


N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) transfers a sulfate group from PAPS to an N-acetylglucosamine residue, which is usually located at the non-reducing end of glycoconjugates. It is important to note that sulfation proceeds the elongation of the glycan chain. This enzyme is involved in the synthesis of keratan sulfate and sialyl 6-sulfo Lewis X, which is present on the luminal surface of the high endothelial venule (HEV) of lymph nodes. So far, five isozymes of GlcNAc6ST have been identified in humans (Table 1). They share about 30% sequence identity, and have the configuration of type II transmembrane proteins, a feature typical of Golgi-located enzymes.


Mucinous Adenocarcinoma Keratan Sulfate High Endothelial Venule Corneal Dystrophy Rolling Velocity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer 2008

Authors and Affiliations

  • Kenji Uchimura
    • 1
  • Takashi Muramatsu
    • 2
  1. 1.Section of Pathophysiology and Neurobiology, Department of Alzheimer’s Disease ResearchNational Institute for Longevity Sciences (NILS)Morioka, Obu, AichiJapan
  2. 2.Department of Health Science, Faculty of Psychological and Physical ScienceAichi Gakuin UniversityNisshin, AichiJapan

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