Carbohydrate Microarray for Deciphering the Information Embedded in Oligosaccharide Structures
The neoglycolipid (NGL) technology for generating lipid-linked oligosaccharide probes has been shown to be an extremely useful tool for detection and characterization of bioactive oligosaccharides that are extremely minor components (Feizi and Child 1994). As the affinities of most carbohydrate-protein interactions are thought to be very low, and the oligosaccharide portions that play a role in biological function are generally believed to be of a small region ranging from monosaccharide to decasaccharide, the neoglycolipid technology is eminently adaptable for microarray design for high-throughput detection and specificity assignments of carbohydrate-protein interactions.
KeywordsHepatocyte Growth Factor Keratinocyte Growth Factor Microarray Design HPTLC Plate Iduronic Acid
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