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Pancreatic Beta Cell in Health and Disease pp 91–110Cite as

Ion Channels and Insulin Secretion

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Abstract

Pancreatic beta cells respond to glucose and other secretagogues with electrical activity. Action potentials are the primary electrical signal of the beta cell and are shaped by the orchestrated flux of ions through various types of ion channels. The expression of a diverse set of ion channels allows dynamic modulation of action potentials in response to multiple input signals. This chapter provides an overview of the ion channels of the beta cell and their role in the regulation of insulin secretion.

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  1. Department of Medicine, The University of Chicago, 5841 S. Maryland Ave., MC1027, Chicago, IL, 60637, USA

    David A. Jacobson & Louis H. Philipson

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  1. David A. Jacobson
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  2. Louis H. Philipson
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  1. Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Susumu Seino M.D., D.M. Sci. (Professor) (Professor)

  2. Medicine and Human Genetics, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA

    Graeme I. Bell Ph.D. (Louis Block Distinguished Service Professor) (Louis Block Distinguished Service Professor)

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Jacobson, D.A., Philipson, L.H. (2008). Ion Channels and Insulin Secretion. In: Seino, S., Bell, G.I. (eds) Pancreatic Beta Cell in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-75452-7_6

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