Metabolic Regulation of Insulin Secretion

  • Barbara E. Corkey


Understanding fuel-induced insulin-secretion cascades is essential to assessing beta-cell pathology in diabetes. Such understanding may pave the way for more effective therapies to treat or prevent diabetes and to maintain islets or surrogate beta cells for transplantation. Metabolic regulation of insulin secretion requires signals reflective of the metabolic state. Signals generally require large rapid changes of limited duration, competitive opposing signals, or ability to translocate. Here we will discuss the metabolic origin and consequences of the following putative metabolic signals that each exhibit such attributes: the adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio (competitive opposition), malonyl CoA (rapid transient)/long chain acyl CoA (LC-CoA) (competitive opposition, translocation), the redox state (competitive opposition), and the role of oscillations (rapid transient).


Insulin Secretion Beta Cell Pancreatic Islet Pancreatic Beta Cell Malic Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Barbara E. Corkey
    • 1
  1. 1.Obesity Research Center, Department of MedicineBoston University School of MedicineBostonUSA

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