Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor

  • Franz M. Matschinsky


The pivotal role of the glucose phosphorylating enzyme glucokinase in glucose homeostasis is discussed, including its established functions as glucose sensor in pancreatic beta cells and as control step in hepatic carbohydrate metabolism. A brief review of “Glucokinase Disease,” a group of hyper- and hypoglycemic clinical phenotypes caused by mutations of the glucokinase gene and inherited as an autosomal dominant trait, and a concise assessment of a newly discovered class of promising antidiabetic drugs that activate glucokinase allosterically, round out this perspective chapter.


Beta Cell Glucose Homeostasis Pancreatic Beta Cell Glucose Sensor Neonatal Diabetes Mellitus 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Franz M. Matschinsky
    • 1
  1. 1.Department of Biochemistry and BiophysicsUniversity of Pennsylvania, School of MedicinePhiladelphiaUSA

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