Architecture of Pancreatic Islets

  • Marcela Brissova
  • Alvin C. Powers


Pancreatic islets are highly vascularized mini-organs that include endocrine cells, endothelial cells, and extracellular matrix. The three-dimensional islet structure and relationship between endocrine cells are different in rodent islets and human islets. This chapter reviews recent studies on the morphology, cell composition, and cell arrangement in human islets and how this may affect islet function.


Beta Cell Pancreatic Islet Endocrine Cell Human Islet Alpha Cell 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Marcela Brissova
    • 1
  • Alvin C. Powers
    • 1
    • 2
    • 3
  1. 1.Division of Diabetes, Endocrinology, and Metabolism, Department of MedicineVanderbilt University Medical CenterNashvilleUSA
  2. 2.Department of Molecular Physiology and BiophysicsVanderbilt University Medical CenterNashvilleUSA
  3. 3.VA Tennessee Valley Healthcare SystemNashvilleUSA

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