Some Patients with Chronic Fatigue Syndrome Have Brain Dysfunction
Chronic fatigue syndrome (CFS) is medically unexplained fatigue lasting at least 6 months and accompanied by infectious, rheumatological, and neuropsychiatric symptoms. CFS is primarily a problem in women’s health because approximately 75% of patients seeking care for chronic fatigue are women. Because of complaints of muscle weakness and achiness, early work focused on peripheral mechanisms of fatigue via muscle dysfunction. However, those studies were unable to confirm any consistent anatomical or physiological abnormality. The lack of an obvious peripheral mechanism for fatigue led to a change in focus to central mechanisms. This change was supported by a set of studies, including those from this laboratory, which showed objective evidence of neuropsychological dysfunction.
KeywordsSingle Photon Emission Compute Tomography Chronic Fatigue Syndrome Gray Matter Volume Chronic Fatigue Syndrome Patient Magnetic Resonance Imaging Abnormality
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