Chronic Fatigue Syndrome and Herpesvirus Infection
Chronic fatigue syndrome (CFS) is a disease of unknown etiology which is accompanied by severe fatigue as a main complaint. The prominence of the acute onset of illness, the persistent symptoms consistent with a viral infection, and the increased titers of viral antibodies and enhanced activity of the interferon-induced enzyme suggest the role of viruses in CFS. In other words, in CFS patients, it is suggested that there may be some kind of “postinfectious fatigue syndrome” following any infection by a virus. Among the variety of viruses evaluated to date are enteroviruses, retroviruses, and human herpesviruses.
CFS is a disease which lasts far longer than postinfectious fatigue. It is considered, accordingly, that the infection causing CFS is a latent infection with some herpesvirus. Human herpesvirus 6 (HHV-6) has exhibited the most promise as a candidate for a CFS-associated virus. As there may be an unusual latent infection with HHV-6, which may be an etiology of CFS in CFS patients, a study of latent infection is considered to be important in understanding CFS.
KeywordsChronic Fatigue Syndrome Latent Infection Hemorrhagic Fever With Renal Syndrome Chronic Fatigue Syndrome Patient Postviral Fatigue Syndrome
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