Neural Basis of Saccadic Decision Making in the Human Cortex
We summarize a few of the brain imaging studies on cortical control of ocular saccades (including the main eye fields: PEF, FEF, SEF, CEF, pre-SEF, PFEF) and describes recent new findings obtained with intracranial recordings of brain activity in epileptic patients (Stereotaxic EEG). We shall particularly focus on the problem of decision making in saccadic control by describing experiments during which subjects had to decide to make an horizontal saccade to a particular direction in space. Oculomotor execution and decision can be studied only by integrating dynamic component. The SEEG signals clearly reveal the multidimensionality of the ensemble neuronal responses, which consist of event-related potentials (ERPs), induced synchronizations and desynchronizations in distinct frequency bands. Our short study show a specific activation in the high frequencies (very high gamma band: 110–140 Hz) of the PFEF in an oculomotor task when the decision is needed.
KeywordsPrefrontal Cortex Transcranial Magnetic Stimulation Antisaccade Task Saccade Generation Saccade Goal
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