What are the characteristics of transition zone cancer? Is it less aggressive than the non-transition-zone cancer?


Transition zone (TZ) cancer is commonly detected in transurethrally resected specimens but also radical prostatectomy specimens. According to a recent study, as many as 14% of stage T1c cancers are exclusively in the TZ. In general, they are small and are of low Gleason score (commonly <6). Because of their anatomic location (away from the “capsule”) and fewer penetrating nerves than in the peripheral zone, they are less likely to behave aggressively than those arising in non-TZs. As the volume increases, however, they may become more aggressive and can invade the anterior fibromuscular stroma, seminal vesicles, and pelvic lymph nodes. Microscopically, most transition zone carcinomas consist of well-differentiated glands of widely variable size and contour lined by tall columnar cells with clear cytoplasm.


Benign Prostate Hyperplasia Seminal Vesicle Gleason Score Pelvic Lymph Node Radical Prostatectomy Specimen 
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