What is the difference between pheochromocytoma and paraganglioma? What are the familial syndromes that have pheochromocytoma as a component? What are the pathologic features of pheochromocytoma indicating malignancy?
The terms pheochromocytoma and paraganglioma are often used interchangeably because morphologically and functionally these entities are the same. Strictly speaking, however, paragangliomas that arise in the adrenal medulla are defined as pheochromocytomas, and those outside the adrenal gland are called paragangliomas. Most of pheochromocytomas and paragangliomas are functional, synthesizing and secreting catecholamines (epinephrine and norepinephrine).
KeywordsAdrenal Medulla Multiple Endocrine Neoplasia Chief Cell Sustentacular Cell Adrenal Pheochromocytoma
Unable to display preview. Download preview PDF.
- 1.Lack EE (1997) Tumors of the adrenal gland and extraadrenal paraganglia. In: Atlas of tumor pathology 19. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
- 2.Kumar V, Abbas AH, Fausto N (2005) Robbin’s pathologic basis of disease. Elsevier Saunders, Philadelphia, pp 1218–1219.Google Scholar
- 3.Glenner GG, Grimley PM (1974) Tumors of the extra-adrenal paraganglion system (including chemoreceptors). In: Atlas of tumor pathology. fascicle 9. Armed Forces Institute of Pathology, Washington DC, p 1.Google Scholar
- 5.Enzinger FM, Weiss SW (1995) Soft tissue tumors. Mosby, St. Louis, pp 965–990.Google Scholar
- 8.Lloyd RV, Blaivas M, Wilson BS (1985) Distribution of chromogranin and S100 protein in normal and abnormal adrenal medullary tissues. Arch Pathol Lab Med 109:33–35.Google Scholar
- 17.Fries JG, Chamberlin JA (1968) Extra-adrenal pheochromocytoma: literature review and report of a cervical pheochromocytoma. Surgery 63:268–279.Google Scholar
- 20.Scott HW Jr, Halter A (1985) Oncologic aspect of pheochromocytoma: the importance of follow-up. Surgery 96:1061–1066.Google Scholar