Skip to main content
SpringerLink
Log in

What is the difference between pheochromocytoma and paraganglioma? What are the familial syndromes that have pheochromocytoma as a component? What are the pathologic features of pheochromocytoma indicating malignancy?

  • Chapter
Questions in Daily Urologic Practice

Abstract

The terms pheochromocytoma and paraganglioma are often used interchangeably because morphologically and functionally these entities are the same. Strictly speaking, however, paragangliomas that arise in the adrenal medulla are defined as pheochromocytomas, and those outside the adrenal gland are called paragangliomas. Most of pheochromocytomas and paragangliomas are functional, synthesizing and secreting catecholamines (epinephrine and norepinephrine).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lack EE (1997) Tumors of the adrenal gland and extraadrenal paraganglia. In: Atlas of tumor pathology 19. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  2. Kumar V, Abbas AH, Fausto N (2005) Robbin’s pathologic basis of disease. Elsevier Saunders, Philadelphia, pp 1218–1219.

    Google Scholar 

  3. Glenner GG, Grimley PM (1974) Tumors of the extra-adrenal paraganglion system (including chemoreceptors). In: Atlas of tumor pathology. fascicle 9. Armed Forces Institute of Pathology, Washington DC, p 1.

    Google Scholar 

  4. Whalen RK, Althausen AF, Daniels GH (1992) Extraadrenal pheochromocytoma. J Urol 147:1–10.

    PubMed  CAS  Google Scholar 

  5. Enzinger FM, Weiss SW (1995) Soft tissue tumors. Mosby, St. Louis, pp 965–990.

    Google Scholar 

  6. Kliewer KE, Cochran AJ (1989) A review of the histology, ultrastructure, immunohistology, and molecular biology of extra adrenal paragangliomas. Arch Pathol Lab Med 113:1209–1218.

    PubMed  CAS  Google Scholar 

  7. Lloyd RV, Shapiro B, Sisson JC, Kalff V, Thompson NW, Beierwaltes WA (1984) An immunohistochemical study of pheochromocytomas. Arch Pathol Lab Med 108:541–544.

    PubMed  CAS  Google Scholar 

  8. Lloyd RV, Blaivas M, Wilson BS (1985) Distribution of chromogranin and S100 protein in normal and abnormal adrenal medullary tissues. Arch Pathol Lab Med 109:33–35.

    Google Scholar 

  9. Unger P, Hoffman K, Pertsemlidis D, Thung S, Wolfe D, Kaneko M (1991) S100 protein-positive sustentacular cells in malignant and locally aggressive adrenal pheochromocytomas. Arch Pathol Lab Med 115:484–487.

    PubMed  CAS  Google Scholar 

  10. Melicow MM (1977) One hundred cases of pheochromocytoma (107 tumors) at the Columbia-Presbyterian Medical Center, 1926–1976: a clinicopathological analysis. Cancer 40:1987–2004.

    Article  PubMed  CAS  Google Scholar 

  11. Modlin IM, Farndon JR, Shepherd A, Johnston ID, Kennedy TL, Montgomery DA, Welbourn RB (1979) Pheochromocytomas in 72 patients: clinical and diagnostic features, treatment and long term results. Br J Surg 66:456–465.

    Article  PubMed  CAS  Google Scholar 

  12. ReMine WH, Chong GC, van Heerden JA, Sheps SG, Harrison EG Jr (1974) Current management of pheochromocytoma. Ann Surg 179:740–747.

    Article  PubMed  CAS  Google Scholar 

  13. van Heerden JA, Sheps SG, Hamberger B, Sheedy PF II, Poston JG, ReMine WH (1982) Pheochromocytoma: current status and changing trends. Surgery 91:367–373.

    PubMed  Google Scholar 

  14. Medeiros LJ, Wolf BC, Balogh K, Federman M (1985) Adrenal pheochromocytoma: a clinicopathologic review of 60 cases. Hum Pathol 16:580–589.

    Article  PubMed  CAS  Google Scholar 

  15. Linnoila RI, Keiser HR, Stenberg SM, Lack EE (1990) Histology of benign versus malignant sympathoadrenal paragangliomas: clinicopathologic study of 120 cases including unusual histologic features. Hum Pathol 21:1168–1180.

    Article  PubMed  CAS  Google Scholar 

  16. Lack EE, Cubilla AL, Woodruff JM, Lieberman PH (1980) Extra-adrenal paragangliomas of the retroperitoneum: a clinicopathologic study of 12 tumors. Am J Surg Pathol 4:109–120.

    Article  PubMed  CAS  Google Scholar 

  17. Fries JG, Chamberlin JA (1968) Extra-adrenal pheochromocytoma: literature review and report of a cervical pheochromocytoma. Surgery 63:268–279.

    Google Scholar 

  18. Hayes WS, Davidson AJ, Grimley PM, Hartman DS (1990) Extraadrenal retroperitoneal paraganglioma: clinical, pathologic and CT findings. AJR Am J Roentgenol 155:1247–1250.

    PubMed  CAS  Google Scholar 

  19. Sclafani LM, Woodruff JM, Brennan MF (1990) Extra-adrenal retroperitoneal paragangliomas: natural history and response to treatment. Surgery 108:1124–1130.

    PubMed  CAS  Google Scholar 

  20. Scott HW Jr, Halter A (1985) Oncologic aspect of pheochromocytoma: the importance of follow-up. Surgery 96:1061–1066.

    Google Scholar 

Download references

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer

About this chapter

Cite this chapter

(2008). What is the difference between pheochromocytoma and paraganglioma? What are the familial syndromes that have pheochromocytoma as a component? What are the pathologic features of pheochromocytoma indicating malignancy?. In: Questions in Daily Urologic Practice. Springer, Tokyo. https://doi.org/10.1007/978-4-431-72819-1_49

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-72819-1_49

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-72818-4

  • Online ISBN: 978-4-431-72819-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation