When a man presents with a germ cell tumor localized in the mediastinum or retroperitoneum, how can one decide whether it is a primary extragonadal tumor or a metastasis?


When the retroperitoneum or mediastinum is the initial manifestation of a germ cell tumor in an adult male, a possibility of metastasis of testicular germ cell tumors must be considered, as the retroperitoneal lymph nodes are the initial site of metastasis of testicular germ cell tumors before they spread further cranially.


Germ Cell Tumor Standardize Incidence Ratio Testicular Tumor Testicular Germ Cell Tumor Retroperitoneal Lymph Node 
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  1. 1.
    Johnson DE, Appelt G, Samuels ML, Luna M (1976) Metastases from testicular carcinoma: study of 78 autopsy cases. Urology 8:234–239.PubMedCrossRefGoogle Scholar
  2. 2.
    Bredael JJ, Vugrin D, Whitmore WF Jr (1982) Autopsy findings in 154 patients with germ cell tumors of the testis. Cancer 50:548–551.PubMedCrossRefGoogle Scholar
  3. 3.
    Boehle A, Studer UE, Sonntag RW, Scheidegger JR (1985) Primary or secondary germ cell tumors? J Urol 135:939–943.Google Scholar
  4. 4.
    Chen KTK, Cheng AC (1989) Retroperitoneal seminoma and intratubular germ cell neoplasia. Hum Pathol 20:493–495.PubMedCrossRefGoogle Scholar
  5. 5.
    Hartmann JT, Fossa SD, Nichols CR, Droz J-P, Horwich A, Gerl A, Beyer J, Pont J, Fizazi K, Hecker H, Kanz L, Einhorn L, Bokemeyer C (2001) Incidence of metachronous testicular cancer in patients with extragonadal germ cell tumors. J Natl Cancer Inst 93:1733–1781.PubMedCrossRefGoogle Scholar
  6. 6.
    Heilemariam S, Engeler DS, Bannwart F, Amin MB (1997) Primary mediastinum germ cell tumor with intratubular germ cell neoplasia of the testis: further support for germ cell origin of these tumors—a case report. Cancer 79:1031–1036.CrossRefGoogle Scholar
  7. 7.
    Daugaard G, Rorth M, von der Masse H, Skakkebaek N (1992) Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies. Ann Oncol 3:283–289.PubMedGoogle Scholar
  8. 8.
    Tynski Z, MacLennan GT (2005) “Burnt-out” testicular germ cell tumors. J Urol 174:2013.PubMedCrossRefGoogle Scholar
  9. 9.
    Balzer BL, Ulbright TM (2006) Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol 30:858–865.PubMedCrossRefGoogle Scholar
  10. 10.
    Henley JD, Young RH, Wade CL, Ulbright TM (2004) Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. Am J Surg Pathol 28:1163–1168.PubMedCrossRefGoogle Scholar

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