What is the latest classification of male germ cell tumors? How do the pathology subtypes relate to their biologic behavior and malignant potential?


Histologically, germ cell tumors (GCTs) mimic early embryogenesis. They consist of a heterogeneous group of tumors. All GCTs in postpubertal males are malignant except for epidermoid cysts. Most GCTs originate in dormant neoplastic cells located inside seminiferous tubules. They are identified as intratubular germ cell neoplasia of unclassified type (IGCNU). Seminoma, the prototype of invasive GCTs, is the most common and accounts for approximately 50% of all GCTs. Nonseminomatous tumors can occur in a pure form, but more commonly they are seen in combination with several types including seminoma.


Embryonal Carcinoma Dermoid Cyst Epidermoid Cyst Endodermal Sinus Tumor Spermatocytic Seminoma 
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