What is the difference between a positive surgical margin and extraprostatic extension in pathology reports of radical prostatectomy? What is the clinical relevance of these findings?


The presence of extraprostatic extension and/or a positive surgical margin in radical prostatectomy specimens predicts an earlier return of measurable serum prostate-specific antigen (PSA) and progression of prostate cancer. Whereas a positive surgical margin often requires additional therapy, such as local irradiation, extraprostatic extension indicates a higher stage but typically does not require immediate therapy unless clinical parameters of overt disease are present.


Radical Prostatectomy Surgical Margin Gleason Score Positive Margin Margin Status 
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