What are the advantages and disadvantages, if any, of the revised (2004) WHO classification of urinary bladder neoplasms?


The World Health Organization (WHO) classification system published in 1973 had been most commonly used in the world until several years ago when this system was challenged. In 1997, a consensus conference was organized by Dr. F.K. Mostofi. It consisted of pathologists, urologists, and oncologists. The meeting was followed by another in 1998 with participation of members of the International Society of Urogical Pathology (ISUP). Recommendations were made to the WHO committee on urothelial tumors. Papillary tumors were divided into four categories: papilloma; papillary urothelial neoplasm of low malignant potential (PUNLMP); carcinoma, low grade (CaLG); and carcinoma, high grade (CaHG). Subsequently, this classification was adopted as the 2004 WHO classification system. As a result, grade 1 carcinomas by the 1973 WHO classification were reclassified as PUNLMP or CaLG; grade 2 carcinomas were assigned to the CaLG and CaHG groups; and grade 3 carcinomas became CaHG.


World Health Organization Urinary Bladder Transitional Cell Carcinoma Urothelial Carcinoma Progression Rate 
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