What is the clinical significance of perineural invasion reported on prostate needle core biopsy?


Although the clinical significance of perineural invasion is a controversial issue, it does not appear to be an independent predictor of extraprostatic extension of cancer. Perineural invasion observed in a prostate needle core biopsy specimen is significantly associated with an increased risk of extraprostatic extension (by univariate logistic analysis), but it is not possible to quantify the magnitude of the risk.


Radical Prostatectomy Perineural Invasion Prostatectomy Specimen High Gleason Score Inferior Pedicle 
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