What are the features of collecting duct carcinoma? What is mucinous tubular spindle cell carcinoma?


What were formerly classified as collecting duct carcinomas consist of four subtypes: (1) classic high-grade collecting duct carcinoma; (2) lowgrade (or tubulocystic) collecting duct carcinomas, both of which are believed to derive from the Bellini duct; (3) medullary (high grade) carcinoma currently identified as a malignant tumor closely related to urothelial cell carcinoma; and (4) mucinous tubular spindle cell carcinoma of low malignant potential presumably of the distal tubule or collecting duct origin. Classic collecting duct carcinoma and medullary carcinoma take a highly aggressive clinical course; they demonstrate an infiltrative growth pattern and spread readily to distant sites. Medullary carcinoma is unique in that it affects black young adults and children, predominantly males, with sickle cell trait or hemoglobin SC disease. Tubulocystic carcinoma is characterized by well-differentiated tubules, which in areas are cystically dilated and give rise to the characteristic “bubble-wrap”-like appearance on the cut surface.


Renal Cell Carcinoma Medullary Carcinoma Papillary Renal Cell Carcinoma Spindle Cell Carcinoma Extracellular Mucin 
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  1. 1.
    Storkel S (2001) Kidney tumors. Workshop presentation at the 18th European Congress of Pathology, Berlin, September 8–13, 2001.Google Scholar
  2. 2.
    Fleming S, Lewi HJE (1986) Collecting duct carcinoma of kidney. Histopathology 10:1131–1141.PubMedCrossRefGoogle Scholar
  3. 3.
    Rumpelt HJ, Stoerkel S, Moll R, Schaerfe T, Thoenes W (1991) Bellini duct carcinoma: further evidence of this rare variant of renal cell carcinoma. Histopathology 18:115–122.PubMedCrossRefGoogle Scholar
  4. 4.
    Aizawa S, Kikuchi Y, Suzuki M, Furusato M (1987) Renal cell carcinoma of lower nephron origin. Acta Pathol Jpn 37:567–574.PubMedGoogle Scholar
  5. 5.
    Kennedy SM, Merino MJ, Linehan WM, Roberts JR, Robertson CN, Neumann RD (1990) Collecting duct carcinoma of the kidney. Hum Pathol 21:449–456.PubMedCrossRefGoogle Scholar
  6. 6.
    Davis CJ, Mostifi FK, Seterhenn IA (1995) Renal medullary carcinoma: the seventh sickle cell nephropathy. Am J Surg Pathol 19:1–11.PubMedCrossRefGoogle Scholar
  7. 7.
    Abrahams JH, Drachenberg M, Beckwith DS (1998) Medullary renal cell carcinoma (MRC): a report of 28 new cases. Mod Pathol 11:74A.Google Scholar
  8. 8.
    Avery RA, Harris JA, Davis CJ, Borgaonkar DS, Byrd JC, Weiss RB (1996) Renal medullary carcinoma: clinical and therapeutic aspects of a newly described tumor. Cancer 78:128–132.PubMedCrossRefGoogle Scholar
  9. 9.
    Yang XJ, Sugimura J, Tretiakova MS, Pins M, Teh BT (2004) Molecular profiling of renal medullary carcinoma. Mod Pathol 17(suppl 1):185A.Google Scholar
  10. 10.
    MacLennan GT, Farrow GM, Bostwick DG (1997) Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology 50:679–684.PubMedCrossRefGoogle Scholar
  11. 11.
    Amin MB, MacLennan GT, Paraf F, Cheville JC, Viellefond A, Radhakrishnan A, Che M, Srigly JR, Grignon DJ (2004) Tubulocystic carcinoma of the kidney: clinicopathological analysis of 29 cases of a distinctive subtype of renal cell carcinoma (RCC). Mod Pathol 17(suppl1):137A.Google Scholar
  12. 12.
    Rakozy C, Schmahl GE, Bohner S, Storkel S (2001) Low grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical and genetic features. Mod Pathol 15:1162–1171.CrossRefGoogle Scholar
  13. 13.
    Fine SW, Argani P, DeMarzo AM, Delahunt B, Sebo TJ, Reuter VE, Epstein JI (2006) Expanding the histologic spectrum of mucinous and spindle cell carcinoma of the kidney. Am J Surg Pathol 30:1554–1560.PubMedCrossRefGoogle Scholar
  14. 14.
    Parwani AV, Husain AN, Epstein JI, Beckwith JB, Argani P (2001) Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation. Hum Pathol 32:506–512.PubMedCrossRefGoogle Scholar

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