What are the features of collecting duct carcinoma? What is mucinous tubular spindle cell carcinoma?
What were formerly classified as collecting duct carcinomas consist of four subtypes: (1) classic high-grade collecting duct carcinoma; (2) lowgrade (or tubulocystic) collecting duct carcinomas, both of which are believed to derive from the Bellini duct; (3) medullary (high grade) carcinoma currently identified as a malignant tumor closely related to urothelial cell carcinoma; and (4) mucinous tubular spindle cell carcinoma of low malignant potential presumably of the distal tubule or collecting duct origin. Classic collecting duct carcinoma and medullary carcinoma take a highly aggressive clinical course; they demonstrate an infiltrative growth pattern and spread readily to distant sites. Medullary carcinoma is unique in that it affects black young adults and children, predominantly males, with sickle cell trait or hemoglobin SC disease. Tubulocystic carcinoma is characterized by well-differentiated tubules, which in areas are cystically dilated and give rise to the characteristic “bubble-wrap”-like appearance on the cut surface.
KeywordsRenal Cell Carcinoma Medullary Carcinoma Papillary Renal Cell Carcinoma Spindle Cell Carcinoma Extracellular Mucin
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