How is chromophobe renal cell carcinoma diagnosed? How does one distinguish chromophobe renal cell carcinoma from oncocytoma?
Chromophobe renal cell carcinoma and oncocytoma have certain features in common. (1) Both are considered to derive from the intercalated cells of collecting ducts. (2) The two have a similar gross appearance (discrete mass, light-tan to brown on the cut surface, irregular fibrous bands or scar in the center). Microscopically, however, they are distinctly different. Chromophobe carcinoma cells grow in solid nests and have prominent cell membranes, reticulated or granular cytoplasm, and a perinuclear transluscent zone. Oncocytoma cells, on the other hand, are deeply eosinophilic owing to abundance in mitochondria and are arranged in cords, nests or tubules. However, distinguishing the eosinophilic variant of chromophobe renal cell carcinoma from oncocytoma may be difficult.
KeywordsRenal Cell Carcinoma Chromophobe Renal Cell Carcinoma Renal Oncocytoma Chromophobe Cell Perinuclear Halo
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- 2.Stoerkel S, Steart PV, Drenckhahn, Thoenes W (1989) The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct. Virchows Arch B Cell Pathol 56:237–245.Google Scholar
- 4.Amin MB, Moch H, Amin M, de Peralta-Venturina M, Stricker H, Tamboli P, Javidan J, Mihatsch M, Menon M (1999) Chromophobe renal cell carcinoma (CHRCC): study of 65 cases. Mod Pathol 12:88A.Google Scholar
- 12.Davis CJ Jr, Sesterhenn IA, Mostofi FK, Ho CK (1991) Renal oncocytoma: clinicopathological study of 166 patients. J Urogenit Pathol 1:41–52.Google Scholar