What is the anatomic structure of the prostate? Where is the transition zone? Where does carcinoma develop? Where does benign prostatic hyperplasia occur?


The prostate consists of four zones: anterior fibromuscular stroma, central zone, peripheral zone, and transition zone. The transition zone is a balloon-shaped component of the prostate that is located in the periurethral region. Most prostatic adenocarcinomas develop in the peripheral zone, although some arise in the transition zone. The transition zone is the exclusive site of benign prostatic hyperplasia (BPH). Both adenocarcinomas and BPH affecting the transition zone may cause urinary obstruction. Carcinomas that develop in the transition zone are generally of the well to moderately differentiated type (Gleason grades 1, 2, 3). Additionally, tumor cells characteristically have pale to clear cytoplasm.


Transition Zone Benign Prostatic Hyperplasia Radical Prostatectomy Central Zone Peripheral Zone 
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