Does granular cell type renal cell carcinoma exist? What are the features of clear cell renal cell carcinoma? What are the pathologic characteristics and the clinical implication of multilocular cystic renal cell carcinoma?


The diagnosis of “granular cell-type renal cell carcinoma (RCC)” should be avoided because it does not represent a true subtype of RCC. So-called granular RCC may actually include several sub-types of RCC or even benign oncocytoma, which may require very different therapy. Clear cell (conventional) RCC is not only the most common type but also is responsible for most of the morbidity and mortality of renal neoplasms. Clear cell RCC, particularly of high grade, can display granular cytoplasm. Multilocular cystic RCC, a new entity in the WHO classification system, represents a low-grade clear cell type RCC with a multilocular cyst.


Clear Cell Granular Cell Cystic Nephroma Placenta Growth Factor Clear Cell RCCs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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