Does granular cell type renal cell carcinoma exist? What are the features of clear cell renal cell carcinoma? What are the pathologic characteristics and the clinical implication of multilocular cystic renal cell carcinoma?
The diagnosis of “granular cell-type renal cell carcinoma (RCC)” should be avoided because it does not represent a true subtype of RCC. So-called granular RCC may actually include several sub-types of RCC or even benign oncocytoma, which may require very different therapy. Clear cell (conventional) RCC is not only the most common type but also is responsible for most of the morbidity and mortality of renal neoplasms. Clear cell RCC, particularly of high grade, can display granular cytoplasm. Multilocular cystic RCC, a new entity in the WHO classification system, represents a low-grade clear cell type RCC with a multilocular cyst.
KeywordsClear Cell Granular Cell Cystic Nephroma Placenta Growth Factor Clear Cell RCCs
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- 4.Wezigmann-Voos S, Breier G, Risau W, Plate K (1995) Up-regulation of vascular endothelial growth factor and its receptor in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res 55: 1358–1364.Google Scholar
- 5.Takahashi A, Sasaki K, Kim SJ, Tobisu K, Kakizoe T, Tsukamoto T, Kumamoto Y, Sugimura T, Terada, M (1994) Marked increased amounts of messenger RNAs for vascular endothelial factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res 54:4233–4237.PubMedGoogle Scholar
- 8.Grignon DJ, Bismar TA, Bianco F, Sakr WA, Pontes JE, Sarkar F, Che M (2004) VHL gene mutations in multilocular cystic renal cell carcinoma: evidence in support of its classification as a type of clear cell renal cell carcinoma. Mod Pathol: 17(Suppl 1)154A.Google Scholar