When a basal cell-specific marker (34βE12 or p63) is negative in an atypical focus, can the diagnosis of adenocarcinoma be rendered? By the same token, if 34βE12- or p63-positive cells are present, can carcinoma be ruled out?
The loss of the basal cell layer is a hallmark of adenocarcinoma of the prostate. Generally speaking, the absence of basal cells as demonstrated by immunohistochemical technique provides strong support for the diagnosis of adenocarcinoma. If an atypical lesion contains basal cells (seen by immunostaining), the diagnosis of adenocarcinoma should be avoided.
KeywordsProstate Cancer Basal Cell Prostate Adenocarcinoma Prostatic Intraepithelial Neoplasia Basal Cell Layer