What is prostatic ductal adenocarcinoma? How is it clinically and pathologically different from the conventional (acinar) adenocarcinoma?
Most adenocarcinomas of the prostate are composed of cuboidal cells characteristic of prostate acini. Therefore, they are defined as acinar adenocarcinoma. Prostate adenocarcinoma characterized by tall columnar cells resembling prostatic ductal cells is defined as ductal adenocarcinoma. Tumor cells are arranged in papillary, complex glandular (cribriform), comedo or solid architectures. Ductal adenocarcinomas usually behave more aggressively than acinar-type adenocarcinoma. They may be periurethral in location and present with hematuria and obstructive symptoms. Ductal adenocarcinoma may occur peripherally without obstructive symptoms and be discovered by prostate needle core biopsy performed for elevated prostate-specific antigen (PSA) levels.
KeywordsRadical Prostatectomy Prostatic Adenocarcinoma Prostatic Intraepithelial Neoplasia Cribriform Pattern Prostatic Duct
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