Epidemiology of Occupational Asthma

  • A. Newman Taylor
  • P. Cullinan
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

Occupational asthma is asthma induced by an agent inhaled at work. This definition implies that an agent inhaled at work has caused or initiated the process of airway inflammation, which is characteristic of asthma (desquamative eosinophilic bronchitis); it distinguishes agents which cause occupational asthma from those which provoke asthma, or cause exacerbations, in those with pre-existing disease. Inducers of occupational asthma can cause asthma [1] through direct injury to the airway epithelium by a respiratory irritant inhaled in toxic concentration (irritant-induced asthma); or [2] as the outcome of an acquired specific hypersensitivity response to (a) an inhaled protein allergen or (b) low molecular weight chemical sensitiser (hypersensitivity-induced asthma).


Airway Hyperresponsiveness Occupational Asthma Snow Crab Latex Allergy European Community Respiratory Health Survey 
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  1. 1.
    Doll R, Peto R, et al (1994) Mortality in relation to smoking: 40 years observations on male British doctors. Br Med J 309:901–911.Google Scholar
  2. 2.
    Doll R, Bradford Hill A (1964) Mortality in relation to smoking. Ten years observation of British male doctors. Br Med J 1:1399–1410.PubMedGoogle Scholar
  3. 3.
    McDonald JC, Keynes H, Meredith S (2000) Reported incidence of occupational asthma in the United Kingdom 1989–1997. Occup Environ Med 57:823–829.PubMedCrossRefGoogle Scholar
  4. 4.
    McDonald JC (2002) The estimated workforce served by occupational physicians in the UK. Occup Med 52:401–406.CrossRefGoogle Scholar
  5. 5.
    Huijdo E, Esterlueyzen T, Rees D, Lalloo UG (2001) Occupational asthma as identified by the Surveillance of Work-related and Occupational and Respiratory Disease Programme in South Africa. Clin Exp Allergy 31:32–39.CrossRefGoogle Scholar
  6. 6.
    Kogevinas M, Zock J-P, Jarvis D et al (2007) Exposure to substances in the workplace and new onset asthma: an international population based study (ECRHS — II). Lancet 370:336–341.PubMedCrossRefGoogle Scholar
  7. 7.
    Balmes J, Becklake M, Blanc PD et al (2003) American Thoracic Society Statement: occupational contribution to the burden of airway disease. Am J Respir Crit Care Med 167:787–797.PubMedCrossRefGoogle Scholar
  8. 8.
    Brooks S, Weiss MA, Bernstein IL (1985) Reactive airways dysfunction syndrome: persistent asthma syndrome after high level irritant exposure. Chest 88:376–384.PubMedCrossRefGoogle Scholar
  9. 9.
    Kern DG (1991) Outbreak of the reactive airways dysfunction syndrome after a spill of glacial acetic acid. Am Rev Respir Dis 144:1056–1064.Google Scholar
  10. 10.
    Sallie BA, McDonald JC (1996) Inhalation accidents reported to the SWORD surveillance project 1990–1993. Ann Occup Hyg 40:211–221.PubMedGoogle Scholar
  11. 11.
    Ross DJ, McDonald JC (1996) Asthma following inhalation accidents reported to SWORD project. Ann Occup Hyg 40:645–650.PubMedGoogle Scholar
  12. 12.
    Flindt MLH. Pulmonary disease due to inhalation of Derivative of Bacillus subtillis containing enzymes. Lancet 1969;i:1181–1184.Google Scholar
  13. 13.
    Pepys J, Hargreaves FE, Longbottom JL, Fowkes J (1969) Allergic reactions of the lungs to enzymes of Bacillus subtilis. Lancet 1:1177–1181.Google Scholar
  14. 14.
    Newhouse ML, Tag B, Pocott SJ, McEwan AC (1970) An epidemiological study of workers producing enzyme washing powders. Lancet 1:689–693.PubMedCrossRefGoogle Scholar
  15. 15.
    Grenenburg M, Milne JF, Watt J (1970) Survey of workers exposed to dust containing derivatives of Bacillus subtilis. Br Med J 2:629–633.Google Scholar
  16. 16.
    Weill H, Waddell IC, Ziskind M, et al (1979) A study of workers exposed to detergent enzymes. JAMA 217:425–433.CrossRefGoogle Scholar
  17. 17.
    Cullinan P, Lowson D, Nieuwenhuijsen MJ et al (1994) Work related symptoms, sensitisation, and estimated exposure in workers not previously exponed to laboratory rats. Occup Environ Med 51:589–592.PubMedGoogle Scholar
  18. 18.
    Cullinan P, Cook A, Gordon S et al (1999) Allergen exposure, atopy and smoking as determinants of allergy to rats in a cohort of laboratory employees. Eur Respir J 13:1139–1143.PubMedCrossRefGoogle Scholar
  19. 19.
    Cullinan P, Cook A, Nieuwenhuijsen M et al (2001) Allergen and dust exposure as determinants of work related symptoms and sensitisation in a cohort of lour exposed workers, a case-control analysis. Ann Occup Hyg 45:97–103.PubMedGoogle Scholar
  20. 20.
    Barker RD, van Tongeren MJA, Harris JM, et al (1998) Risk factors for sensitisation and respiratory symptoms among workers exposed to acid anhydrides: a cohort study. Occup Environ Med 55:684–691.PubMedCrossRefGoogle Scholar
  21. 21.
    Juniper CP, Howe W, Goodwin BFJ, Kinshott AK (1977) Bacillus subtilis enzymes: a 7 year clinical epidemiological and immunological study of an industrial allergen. J Soc Occup Med 27:3–12.PubMedCrossRefGoogle Scholar
  22. 22.
    Cathcart M, Nicholson P, Roberts D et al (1997) Enzyme exposure, smoking and lung function in employees in the detergent industry over 20 years. Medical Subcommittee of UK Soap and Detergent Industry Association Occup Med Lond 47:473–478.Google Scholar
  23. 23.
    Cullinan P, Harris JM, Newman Taylor AJ et al (2000) An outbreak of asthma in a modern detergent factory. Lancet 356:1899–1900.PubMedCrossRefGoogle Scholar
  24. 24.
    Allmers H, Schmengler J, Skudlek C (2002) Primary prevention of natural rubber latex allergy I the German healthcare system through education and intervention. J Allergy Clin Immunol 110:318–323.PubMedCrossRefGoogle Scholar
  25. 25.
    Tarlo SM, Liss GM, Yeung KS (2002) Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures. Occup Environ Med 159:58–62.CrossRefGoogle Scholar
  26. 26.
    Botham PA, Davies GE, Teasdale EL (1987) Allergy to laboratory animals: a prospective study of its incidence and the influence of atopy on its development. Br J Ind Med 44:627–632.PubMedGoogle Scholar
  27. 27.
    Malo J-L, cartier A, Ghezzo H, Lafrance M, McCantz M, Lehrer S (1988) Patterns of improvement in spirometry, bronchial hyper-responsiveness and specific IgE antibody levels after cessation of exposure in occupational asthma caused by snow crab processing. Am Rev Respir Dis 138:807–812.PubMedGoogle Scholar
  28. 28.
    Venables KM, Toping MD, Nunn AJ, Howe W, Newman Taylor AJ (1987) Immunologic and functional consequences of chemical (tetrachlorophthalic anhydride) induced asthma after four years of avoidance of exposure. J Allergy Clin Immunol 80:212–218.PubMedCrossRefGoogle Scholar
  29. 29.
    Slovak AJM, Hill RN (1981) Laboratory animal allergy: a clinical survey of an exposed population. Br J Ind Med 38:38–41.PubMedGoogle Scholar
  30. 30.
    Lozewicz S, Assoufi BK, Hawkins R, Newman Taylor AJ (1987) Outcome of asthma induced by isocyanates. Br J Dis Chest 81:14–22.PubMedCrossRefGoogle Scholar
  31. 31.
    Ross DJ, McDonald JC (1998) Health and employment after a diagnosis of occupational asthma. Occup Med 48:219–225.CrossRefGoogle Scholar
  32. 32.
    Weir DC, Robertson JF, Jones S, Burge PS (1987) The economic consequences of developing occupational asthma. Thorax 42:209.Google Scholar
  33. 33.
    Venables KM, Davison AG, Newman Taylor AJ (1989) Consequences of occupational asthma. Resp Med 83:437–440.CrossRefGoogle Scholar
  34. 34.
    Rachiotis G, Savani R, Brant A, MacNeill SJ, Newman Taylor A, Cullinan P (2007) Outcome of occupational asthma after cessation of exposure: a systematic review. Thorax 62:147–152.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  • A. Newman Taylor
    • 1
  • P. Cullinan
    • 1
  1. 1.Department of Occupational and Environmental MedicineImperial College, National Heart and Lung Institute, Brompton CampusLondonUK

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