Epidemiology of Asthma and Allergic Rhinitis

  • Deborah Jarvis
  • Seif Shaheen
  • Peter Burney
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

Asthma and allergic rhinitis are common chronic conditions in children and adults in many parts of the world and the prevalence of both increased substantially during the twentieth century. Many people suffer from both asthma and allergic rhinitis and this is usually attributed to a shared link with IgE sensitisation to common environmental allergens. Despite extensive research into the environmental and lifestyle causes of asthma and allergic rhinitis no single factor has been identified to explain the marked geographical variation or the time trends in disease prevalence.

In this chapter, we will review the burden of both diseases, consider the risk factors that have been implicated in their aetiology and comment on the pattern of association of the two conditions.


Allergic Rhinitis Allergy Clin Immunol Respir Crit House Dust Mite Allergen European Community Respiratory Health Survey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    CIBA Guest Symposium (1959) Terminology, definitions and classification of chronic pulmonary emphysema and related conditions. Thorax 14:286–299.Google Scholar
  2. 2.
    American College of Physicians and American Thoracic Society (1975) Pulmonary terms and symbols. Chest 67:583–593.CrossRefGoogle Scholar
  3. 3.
    N. H. L. a. B. I. National Institutes of Health (1992) International consensus report on diagnosis and treatment of asthma. Eur Respir J 5:601–642.Google Scholar
  4. 4.
    World Health Organisation (1975) Epidemiology of chronic non-specific respiratory disease. Bull WHO 52:251–259.Google Scholar
  5. 5.
    Burney PG, Luczynska C, Chinn S, Jarvis D (1994) The European Community Respiratory Health Survey. Eur Respir J 7:954–960.PubMedGoogle Scholar
  6. 6.
    Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW, Mitchell (1995) International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 8:483–491.PubMedCrossRefGoogle Scholar
  7. 7.
    Wenzel SE (2006) Asthma: defining of the persistent adult phenotypes. Lancet 368:804–813.PubMedCrossRefGoogle Scholar
  8. 8.
    American Thoracic Society (2000) Guidelines for methacholine and exercise challenge testing. Am J Respir Crit Care Med 161:309–329.Google Scholar
  9. 9.
    European Respiratory Society (1993) Airway responsiveness: standardised challenge testing with pharmacological, physical and sensitising stimuli in adults. Eur Respir J 6 (S16):53–83.Google Scholar
  10. 10.
    Chinn S (1998) Methodology of bronchial responsiveness. Thorax 53:984–988.PubMedGoogle Scholar
  11. 11.
    Cockcroft D, Davis BE (2006) Mechanisms of airway hyperresponsiveness. J Allergy Clin Immunol 118:551–559.PubMedCrossRefGoogle Scholar
  12. 12.
    Burney P (1987) A diet rich in sodium may potentiate asthma. Epidemiologic evidence for a new hypothesis. Chest 91:143S–148S.Google Scholar
  13. 13.
    Bousquet J, van Cauwenberge P, Khaltaev N (2001) Allergic rhinitis and its impact on asthma; Workshop report. J Allergy Clin Immunol 108. l1=2l2=2intld=94
  14. 14.
    European Community Respiratory Health Survey (1996) Variations in the prevalence of respiratory symptoms, self- reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 9:687–695.CrossRefGoogle Scholar
  15. 15.
    Chinn S, Burney P, Jarvis D, Luczynska C (1997) Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 10:2495–2501.PubMedCrossRefGoogle Scholar
  16. 16.
    Masoli M, Fabian D, Holt S, Beasley R (2004) Global burden of asthma. Accessed 2/09/08
  17. 17.
    International Study of Asthma and Allergies in Childhood Steering Committee (1998) Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema: ISAAC. Lancet 351:1225–1232.CrossRefGoogle Scholar
  18. 18.
    (1988) In: Holland W (ed). The european community:atlas of avoidable death. Oxford University Press, Oxford.Google Scholar
  19. 19.
    Hunt Jr LW, Silverstein MD, Reed CE, O'Connell EJ, O'Fallon WM, Yunginger JW (1993) Accuracy of the death certificate in a population-based study of asthmatic patients. JAMA 269:1947–1952.PubMedCrossRefGoogle Scholar
  20. 20.
    Sears MR, Hiller H, Boer G, Beaglehole B, Gillies A, Holst P, O'Donnell T, Rothwell R (1986) Accuracy of certification of deaths due to asthma—a national study. Am J Epidemiol 124:1004–1011.PubMedGoogle Scholar
  21. 21.
    Subcommittee of the BTA Research Committee (1984) Accuracy of death certificates in bronchial asthma. Accuracy of certification procedures during the confidential inquiry by the British Thoracic Association. Thorax 39:505–509.Google Scholar
  22. 22.
    Guite HF, Burney PG (1996) Accuracy of recording of deaths from asthma in the UK: the false negative rate. Thorax 51:924–928.PubMedGoogle Scholar
  23. 23.
    Burney P, Papacosta AO, Withey C, Colley J, Holland W (1991) Hospital admission rates and the prevalence of asthma symptoms in 20 local authority districts. Thorax 46:574–579.PubMedGoogle Scholar
  24. 24.
    The International Study of Asthma and Allergies in Childhood (ISSAC) Steering Committee (1988) Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC) [see comments]. Eur Respir J 12:315–335.Google Scholar
  25. 25.
    Strachan D, Sibbald B, Weiland S, Ait-Khaled N, Anabwani G, Anderson HR, Asher IM, Beasley R, Bjorksten B, Burr M, Clayton TO, Crane J, Ellwood PE, Keil U, Lai CK, Mallol J, Martinez F, Mitchell EA, Montefort S, Pearce N, C.Robertson CF, Shah JR, Stewart AW, von Mutius E, Williams HC (1997) Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr Allergy Immunol 8:161–176.PubMedCrossRefGoogle Scholar
  26. 26.
    Burney P (2002) The changing prevalence of asthma. Thorax 57:ii0–ii3.Google Scholar
  27. 27.
    Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, Williams H; ISAAC Phase Three Study Group (2006) Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 368(9537):733–743.CrossRefGoogle Scholar
  28. 28.
    Pearce N, it-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, Robertson C; ISAAC Phase Three Study Group (2007) Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 62:757–765.CrossRefGoogle Scholar
  29. 29.
    Chinn S, Jarvis D, Burney P, Luczynska C, Ackermann-Liebrich U, Anto JM, Cerveri I, de Marco R, Gislason T, Heinrich J, Janson C, Kunzli N, Leynaert B, Neukirch F, Schouten J, Sunyer J, Svanes C, Vermeire P, Wjst M (2004) Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey. Thorax 59:646–651.PubMedCrossRefGoogle Scholar
  30. 30.
    Wieringa MH, Vermeire PA, Brunekreef B, Weyler JJ (2001) Increased occurrence of asthma and allergy: critical appraisal of studies using allergic sensitization, bronchial hyper-responsiveness and lung function measurements. Clin Exp Allergy 31:1553–1563.PubMedCrossRefGoogle Scholar
  31. 31.
    Burr ML, Miskelly FG, Butland B, Merrett TG, Vaughan-Williams E (1989) Environmental factors and symptoms in infants at high risk of allergy. J Epidemol Comm Health 43:125–132.CrossRefGoogle Scholar
  32. 32.
    Burr ML, Wat D, Evans C, Dunstan FDJ, Doull IJM; on behalf of the British Thoracic Society Research Committee (2006) Asthma prevalence in 1973, 1988 and 2003. Thorax 61:296–299.PubMedCrossRefGoogle Scholar
  33. 33.
    Peat JK, van den Berg RH, Green WF, Mellis CM, Leeder SR, Woolcock A (1994) Changing prevalence of asthma in Australian children. BMJ 308:1591–1596.PubMedGoogle Scholar
  34. 34.
    Peat JK, Haby M, Spijker J, Berry G, Woolcock A (1992) Prevalence of asthma in adults in Busselton, Western Australia. BMJ 305:1326–1329.PubMedGoogle Scholar
  35. 35.
    Dubois P, Degrave E, Vandenplas O (1998) Asthma and airway hyperresponsiveness among Belgian conscripts. 1978–91. Thorax 53:101–105.PubMedGoogle Scholar
  36. 36.
    Anderson HR (1989) Increase in hospital admissions for childhood asthma: trends in referral, severity, and readmissions from 1970 to 1985 in a health region of the United Kingdom. Thorax 44:614–619.PubMedGoogle Scholar
  37. 37.
    Anderson HR, Gupta R, Strachan DP, Limb ES (2007) 50 years of asthma: UK trends from 1955 to 2004. Thorax 62:85–90.PubMedCrossRefGoogle Scholar
  38. 38.
    Hyndman SJ, Williams DR, Merrill SL, Lipscombe JM, Palmer CR (1994) Rates of admission to hospital for asthma. BMJ 308:1596–1600.PubMedGoogle Scholar
  39. 39.
    Vollmer W, Osborne M, Buist S (1993) Temporal trends in hospital based episodes of asthma care in health maintenance organisation. Am Rev Respir Dis 147:347–353.PubMedGoogle Scholar
  40. 40.
    Fleming DM, Crombie DL (1987) Prevalence of asthma and hay fever in England and Wales. BMJ Clin Res Ed 294:279–283.Google Scholar
  41. 41.
    Fleming DM, Sunderland R, Cross KW, Ross AM (2000) Declining incidence of episodes of asthma: a study of trends in new episodes presenting to general practitioners in the period 1989–98. Thorax 55:657–661.PubMedCrossRefGoogle Scholar
  42. 42.
    Gupta R, Sheikh A, Strachan DP, Anderson HR (2007) Time trends in allergic disorders in the UK. Thorax 62:91–96.PubMedCrossRefGoogle Scholar
  43. 43.
    Burr ML, Butland B, King S, Vaughan-Williams E (1989) Changes in asthma prevalence;two surveys 15 years apart. Arch Dis Child 64:1452–1456.PubMedGoogle Scholar
  44. 44.
    Ninan TK, Russell G (1992) Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart [published erratum appears in BMJ 1992;304(6835):1157]. BMJ 304:873–875.PubMedGoogle Scholar
  45. 45.
    Anderson HR, Pottier AC, Strachan DP (1992) Asthma from birth to age 23: incidence and relation to prior and concurrent atopic disease. Thorax 47:537–542.PubMedGoogle Scholar
  46. 46.
    Broder I, Higgins MW, Mathews KP, Keller JB (1974) Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan: IV. Natural history. J Allergy Clin Immunol 54:100–110.PubMedCrossRefGoogle Scholar
  47. 47.
    Yunginger JW, Reed CE, O'Connell EJ, Melton LJ, O'Fallon WM, Silverstein MD (1992) A community-based study of the epidemiology of asthma. Incidence rates, 1964–1983. Am Rev Respir Dis 146:888–894.PubMedGoogle Scholar
  48. 48.
    Nicolai T, Carr D, Weiland SK, Duhme H, von EO, Wagner C, von Mutius E. (2003) Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children. Eur Respir J 21:956–963.PubMedCrossRefGoogle Scholar
  49. 49.
    Becklake MR, Kauffmann F (1999) Gender differences in airway behaviour over the human life span. [see comment]. Thorax 54(12):1119–1138.PubMedGoogle Scholar
  50. 50.
    Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ, Halonen M (1995) Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 332:133–138.Google Scholar
  51. 51.
    Kelly W, Hudson I, Phelan PD, Pain M, Olinsky A (1987) Childhood asthma in adult life; afurther study at 28 years of age. BMJ 294:1059–1062.PubMedGoogle Scholar
  52. 52.
    Bronnimann S, Burrows B (1986) A propective study of the natural history of asyhma; remission and relapse rates. Chest 90:480–484.PubMedCrossRefGoogle Scholar
  53. 53.
    Lewis S, Richards D, Bynner J, Butler N, Britton J (1995) Prospective study of risk factors for early and persistent wheezing in childhood. Eur Resp J 8(3):349–56.CrossRefGoogle Scholar
  54. 54.
    Strachan DP, Butland B, Anderson HR, Butland BK (1996) Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British birth cohort. BMJ 312:1195–1199.PubMedGoogle Scholar
  55. 55.
    Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Silva PA, Poulton R (2003) A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 349:1414–1422.PubMedCrossRefGoogle Scholar
  56. 56.
    Lange P, Ulrik CS, Vestbo J; for the Copenhagan City Heart Study Group (1996) Mortality in adults with self-reported asthma. Lancet 347:1285–1289.PubMedGoogle Scholar
  57. 57.
    Panizza JA, James AL, Ryan G, de Klerk N, Finucane KE (2006) Mortality and airflow obstruction in asthma: a 17-year follow-up study. Intern Med J 36:773–780.PubMedCrossRefGoogle Scholar
  58. 58.
    Beaty TH, Cohen BH, Newill CA, Menkes HA, Diamond EL, Chen CJ (1982) Impaired pulmonary function as a risk factor for mortality. Am J Epidemiol 116:102–113.PubMedGoogle Scholar
  59. 59.
    Strachan DP, Griffiths JM, Johnston ID, Anderson HR (1996) Ventilatory function in British adults after asthma or wheezing illness at ages 0–35. Am J Respir Crit Care Med 154:1629–1635.PubMedGoogle Scholar
  60. 60.
    Berhane K, Mc Connell R, Gilliland F, Islam T, Gauderman J, Avol E, London S, Rappaport E, Margolis G, Peters J (2000) Sex-specific effects of asthma on pulmonary function in children. Am J Respir Crit Care Med 162:1723–1730.PubMedGoogle Scholar
  61. 61.
    Strunk RC, Weiss ST, Yates KP, Tonascia J, Zeiger RS, Szefler SJ (2006) Mild to moderate asthma affects lung growth in children and adolescents. J Allergy Clin Immunol 118:1040–1047.PubMedCrossRefGoogle Scholar
  62. 62.
    Borsboom GJ, Van PW, Quanjer PH (1993) Pubertal growth curves of ventilatory function: relationship with childhood respiratory symptoms. Am Rev Respir Dis 147:372–378.PubMedGoogle Scholar
  63. 63.
    Baatenburg de Jong A, Brouwer AFJ, Roorda RJ, Brand PLP (2006) Normal lung function in children with mild to moderate persistent asthma well controlled by inhaled corticosteroids. J Allergy Clin Immunol 118:280–282.CrossRefGoogle Scholar
  64. 64.
    Lange P, Vestbo J, Schnohr P, Jensen G (1998) A 15 year follow-up study of ventilatory function in adults with asthma. N Engl J Med 339:1194–1200.PubMedCrossRefGoogle Scholar
  65. 65.
    Peat JK, Woolcock A, Cullen K (1987) Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 70:171–179.PubMedGoogle Scholar
  66. 66.
    Lange P, Scharling H, Ulrik CS, Vestbo J (2006) Inhaled corticosteroids and decline of lung function in community residents with asthma see comment]. Thorax 61:100–104.PubMedCrossRefGoogle Scholar
  67. 67.
    de Marco R, Marcon A, Jarvis D, Accordini S, Almar E, Bugiani M, Carolei A, Cazzoletti L, Corsico A, Gislason D, Gulsvik A, Jogi R, Marinoni A, Martinez-Moratalla J, Pin I, Janson C (2006) Prognostic factors of asthma severity: A 9-year international prospective cohort study. J Allergy Clin Immunol 117:1249–1256.PubMedCrossRefGoogle Scholar
  68. 68.
    Broder I, Higgins MW, Mathews KP, Keller JB (1974) Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan: III. Second survey of the community. J Allergy Clin Immunol 53:127–138.Google Scholar
  69. 69.
    Kulig M, Klettke U, Wahn V, Forster J, Bauer CP, Wahn U (2000) Development of seasonal allergic rhinitis during the first 7 years of life. J Allergy Clin Immunol 106(5):832–839.PubMedCrossRefGoogle Scholar
  70. 70.
    Huurre TM, Aro HM, Jaakkola JJ (2004) Incidence and prevalence of asthma and allergic rhinitis: a cohort study of Finnish adolescents. J Asthma 41(3):311–317.PubMedCrossRefGoogle Scholar
  71. 71.
    Strachan DP (1995) Epidemiology of rhinitis. In: Busse W, Holgate S (eds), Asthma and rhinitis. Blackwell Science, London, pp 33–42.Google Scholar
  72. 72.
    Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M, Neukirch F (2004) Association between asthma and rhinitis according to atopic sensitization in a populationbased study. J Allergy Clin Immunol 113(1):86–93.PubMedCrossRefGoogle Scholar
  73. 73.
    Guerra S, Sherrill DL, Martinez FD, Barbee RA (2002) Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 109:419–425.PubMedCrossRefGoogle Scholar
  74. 74.
    Sherrill DL, Guerra S, Cristina Minervini M, Wright AL, Martinez FD (2005) The relation of rhinitis to recurrent cough and wheezing: a longitudinal study. Respir Med 99:1377–1385.PubMedCrossRefGoogle Scholar
  75. 75.
    Barnes KC (2006) Genetic epidemiology of health disparities in allergy and clinical immunology. J Allergy Clin Immunol 117(2):243–254.PubMedCrossRefGoogle Scholar
  76. 76.
    Joseph CL, Ownby DR, Peterson EL, Johnson CC (2000) Racial differences in physiologic parameters related to asthma among middle-class children. Chest 117(5):1336–1344.PubMedCrossRefGoogle Scholar
  77. 77.
    Schwartz J, Gold D, Dockery DW, Weiss ST, Speizer FE (1990) Predictors of asthma and persistent wheeze in a national sample of children in the United States. Association with social class, perinatal events, and race. Am Rev Respir Dis 142:555–562.Google Scholar
  78. 78.
    Keeley DJ, Neill P, Gallivan S (1991) Comparison of the prevalence of reversible airways obstruction in rural and urban Zimbabwean children. Thorax 46:549–553.PubMedGoogle Scholar
  79. 79.
    Pattemore PK, Ellison-Loschmann L, Asher MI, Barry DM, Clayton TO, Crane J, D'Souza WJ, Ellwood P, Ford RP, Mackay RJ, Mitchell EA, Moyes C, Pearce N, Stewart AW; ISAAC (2004) Asthma prevalence in European, Maori, and Pacific children in New Zealand: ISAAC study. Pediatr Pulmonol 37(5):433–442.PubMedCrossRefGoogle Scholar
  80. 80.
    Downs SH, Marks GB, Belosouva EG, Peat JK (2001) Asthma and hayfever in Aboriginal and non-Aboriginal children living in non-remote rural towns.[see comment]. Med J Aust 175:10–13.PubMedGoogle Scholar
  81. 81.
    Peat JK, Veale A (2001) Impact and aetiology of respiratory infections, asthma and airway disease in Australian Aborigines. J Paediatr Child Health 37:108–112.PubMedCrossRefGoogle Scholar
  82. 82.
    Carey OJ, Cookson JB, Britton JR, Tattersfield AE (1996) The effect of lifestyle on wheeze, atopy, and bronchial hyperreactivity in Asian and white children. Am J Respir Crit Care Med 154:537–540.PubMedGoogle Scholar
  83. 83.
    Jarvis T, Krieger N, Van Den Eeden S, Quesenberry C (2002) Different slopes for different folks: socioeconomic and racial/ethnic disparities in asthma and hay fever among 173,859 men and women. Environ Health Perspect 110:211–216.Google Scholar
  84. 84.
    Stewart AW, Mitchell EA, Pearce N, Strachan DP, Weilandon SK; ISAAC Steering Committee. International Study for Asthma and Allergy in Childhood (2001) The relationship of per capita gross national product to the prevalence of symptoms of asthma and other atopic diseases in children (ISAAC) [see comments]. Int J Epidemiol 30:173–179.PubMedCrossRefGoogle Scholar
  85. 85.
    Rona RJ, Hughes JM, Chinn S (1999) Association between asthma and family size between 1977 and 1994. J Epidemiol Commun Health 53:15–19.CrossRefGoogle Scholar
  86. 86.
    Rona RJ (2000) Asthma and poverty. Thorax, 55:239–244.PubMedCrossRefGoogle Scholar
  87. 87.
    Sibbald B, Rink E (1991)Labelling of rhinitis and hayfever by doctors. Thorax 46:378–381.PubMedCrossRefGoogle Scholar
  88. 88.
    Mercer MJ, Joubert G, Ehrlich RI, Nelson H, Poyser MA, Puterman A, Weinberg EG (2004) Socioeconomic status and prevalence of allergic rhinitis and atopic eczema symptoms in young adolescents. Pediatr Allergy Immunol 15(3):234–41.PubMedCrossRefGoogle Scholar
  89. 89.
    Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299:1259–1260.PubMedGoogle Scholar
  90. 90.
    Karmaus W, Botezan C (2002) Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Commun Health 56:209–217.CrossRefGoogle Scholar
  91. 91.
    Svanes C, Jarvis D, Chinn S, Omenaas E, Gulsvik A, Burney P (2002) Early exposure to children in family and day care as related to adult asthma and hay fever: results from the European Community Respiratory Health Survey. Thorax 57:845–950.CrossRefGoogle Scholar
  92. 92.
    Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL (2000) Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 343:538–543.PubMedCrossRefGoogle Scholar
  93. 93.
    Kramer U, Heinrich J, Wjst M, Wichmann HE (1999) Age of entry to day nursery and allergy in later childhood. Lancet 353:450–454.PubMedCrossRefGoogle Scholar
  94. 94.
    J. Sunyer, J. M. Anto, J. Harris, M. Torrent, O. Vall, P. Cullinan, A. Newman-Taylor, and AMICS study (2001)Asthma Multi-centre, Maternal atopy and parity. Clin Exp Allergy 31:1352–1355.PubMedCrossRefGoogle Scholar
  95. 95.
    Harris JM, White C, Moffat S, Mills P, Newman Taylor AJ, Cullinan P (2004) New pregnancies and loss of allergy. Clin Exp Allergy 34:369–372.PubMedCrossRefGoogle Scholar
  96. 96.
    Sunyer J, Anto JM, Plana E, Janson C, Jarvis D, Kony S, Omenaas E, Svanes C, Wjst M, Leynaert B (2005) Maternal atopy and changes in parity. Clin Exp Allergy 35:1028–1032.PubMedCrossRefGoogle Scholar
  97. 97.
    Tata LJ, Hubbard RB, McKeever TM, Smith CJP, Doyle P, Smeeth L, West J, Lewis SA (2007) Fertility rates in women with asthma, eczema, and hay fever: a general population-based cohort study. Am J Epidemiol kwk092.Google Scholar
  98. 98.
    Westergaard T, Begtrup K, Rostgaard K, Krause TG, Benn CS, Melbye M (2003) Reproductive history and allergic rhinitis among 31145 Danish women, Clin Exp Allergy 33:301–305.PubMedCrossRefGoogle Scholar
  99. 99.
    Matricardi P, Franzinelli F, Franco A, Caprio G, Murru F, Cioffi D, Ferrigno L, Palermo A, Ciccarelli N, Rosmini F (1998) Sibship size, birth order and atopy in 11,371 Italian young men. J Allergy Clin Immunol 101:439–444.PubMedCrossRefGoogle Scholar
  100. 100.
    Westergaard T, Rostgaard K, Wohlfahrt J, Andersen PK, Aaby P, Melbye M (2005) Sibship characteristics and risk of allergic rhinitis and asthma. Am J Epidemiol 162:125–132.PubMedCrossRefGoogle Scholar
  101. 101.
    Strachan DP, Taylor EM, Carpenter RG (1996) Family structure, neonatal infection, and hay fever in adolescence. Arch Dis Child 74:422–426.PubMedGoogle Scholar
  102. 102.
    Shaheen SO, Aaby P, Hall A, Barker DJ, Heyes CB, Shiell AW (1996) Measles and atopy in Guinea-Bissau. Lancet 347:1792–1796.PubMedCrossRefGoogle Scholar
  103. 103.
    Matricardi P, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne, Stroffolini T, Pasquini P, D'Amelio R (1997) Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 314:999–1003.PubMedGoogle Scholar
  104. 104.
    Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, Bonini S (2000) Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 320:412–417.PubMedCrossRefGoogle Scholar
  105. 105.
    Jarvis D, Luczynska C, Chinn S, Burney P (2004) The association of hepatitis A and Helicobacter pylori with sensitization to common allergens, asthma and hay fever in a population of young British adults. Allergy 58:1063–1067.CrossRefGoogle Scholar
  106. 106.
    Law M, Morris JK, Wald N, Luczynska C, Burney P (2005) Changes in atopy over a quarter of a century, based on cross sectional data at three time periods. BMJ 330:1187–1188.PubMedCrossRefGoogle Scholar
  107. 107.
    Bjorksten B, Naaber P, Sepp E, and Mikelsaar M (1999) The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy 342–346.Google Scholar
  108. 108.
    Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F, Adams H, van Ree R, Stobberingh EE (2007) Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut 56:661–667.PubMedCrossRefGoogle Scholar
  109. 109.
    Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E (2001) Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet, 357:1076–1079.PubMedCrossRefGoogle Scholar
  110. 110.
    Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri E (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361:1869–1871.PubMedCrossRefGoogle Scholar
  111. 111.
    Farooqi IS, Hopkin JM (1998) Early childhood infection and atopic disorder. Thorax 53:927–932.PubMedGoogle Scholar
  112. 112.
    Celedon JC, Litonjua AA, Ryan L, Weiss ST, Gold DR (2002) Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years. Am J Respir Crit Care Med 166:72–75.PubMedCrossRefGoogle Scholar
  113. 113.
    Harris JM, Mills P, White C, Moffat S, Newman Taylor AJ, Cullinan P (2007) Recorded infections and antibiotics in early life: associations with allergy in UK children and their parents. Thorax 62:631–637.PubMedCrossRefGoogle Scholar
  114. 114.
    Alm JA, Swartz J, Lilha G, Scheynius A, Pershagen G (1999) Atopy in children of families with an anthroposophic lifestyle. Lancet 353:1485–1488.PubMedCrossRefGoogle Scholar
  115. 115.
    Floistrup H, Swartz J, Bergstrom A, Alm JS, Scheynius A, van Hage M, Waser M, Braun-Fahrlander C, Schram-Bijkerk D, Huber M, Zutavern A, von Mutius E, Ublagger E, Riedler J, Michaels KB, Pershagen G; PARSIFAL Study Group (2006) Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 117:59–66.PubMedCrossRefGoogle Scholar
  116. 116.
    McKeever TM, Lewis SA, Smit HA, Burney P, Britton JR, Cassano PA (2005) The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function. Am J Respir Crit Care Med 171:966–971.PubMedCrossRefGoogle Scholar
  117. 117.
    Shaheen SO, Sterne JA, Songhurst CE, Burney PG (2000) Frequent paracetamol use and asthma in adults. Thorax 55:266–270.PubMedCrossRefGoogle Scholar
  118. 118.
    Barr RG, Wentowski CC, Curhan GC, Somers SC, Stampfer MJ (2004) Prospective study of acetaminophen use and newly diagnosed asthma among women. Am J Respir Crit Care Med 169:836–841.PubMedCrossRefGoogle Scholar
  119. 119.
    Shaheen SO, Newson RB, Henderson AJ, Headley JE, Stratton FD, Jones RW, Strachan DP; the ALSPAC Study Team (2005) Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy 35:18–25.PubMedCrossRefGoogle Scholar
  120. 120.
    Braun-Fahrlander C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wuthrich B (1999) Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss study on childhood allergy and respiratory symptoms with respect to air pollution. Clin Exp Allergy 29:28–34.Google Scholar
  121. 121.
    Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D,von Mutius E; ALEX Study Team (2001) Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 358:1129–1133.PubMedCrossRefGoogle Scholar
  122. 122.
    Leynaert B, Neukirch C, Jarvis D, Chinn S, Burney P, Neukirch F (2001) Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood? Am J Respir Crit Care Med 164:1829–1834.PubMedGoogle Scholar
  123. 123.
    Perkin MR, Strachan DP (2006) Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J Allergy Clin Immunol 117:1374–1381.PubMedCrossRefGoogle Scholar
  124. 124.
    Ege MJ, Frei R, Bieli C, Schram-Bijkerk D, Waser M, Benz MR, Weiss G, Nyberg F, van Hage M, Pershagen G, Brunekreef B, Riedler J, Lauener R, Braun-Fahrlander C, von Mutius E; the PARSIFAL Study team (2007) Not all farming environments protect against the development of asthma and wheeze in children. J Allergy Clin Immunol 119:1140–1147.PubMedCrossRefGoogle Scholar
  125. 125.
    Nilsson L, Kjellman N-IM, Bjorksten B (1998) A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med 152:734–738.PubMedGoogle Scholar
  126. 126.
    T. Shirakawa, T. Enomoto, S. Shimazu, and J. M. Hopkin, The inverse association between tuberculin responses and atopic disorder. Science 275 (1997) 77–79.PubMedCrossRefGoogle Scholar
  127. 127.
    Marks GB, Ng K, Zhou J, Toelle BG, Xuan W, Belousova EG, Britton WJ (2003) The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: An historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease. J Allergy Clin Immunol 111:541–549.PubMedCrossRefGoogle Scholar
  128. 128.
    Aaby P, Shaheen SO, Heyes CB, Goudiaby A, Hall AJ, Shiell AW, Jensen H, Marchant A (2000) Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy 30:644–650.PubMedCrossRefGoogle Scholar
  129. 129.
    Alm JS, Lilja G, Pershagen G, Scheynius A (1998) BCG vaccination does not seem to prevent atopy in children with atopic heredity. Allergy 53:537.PubMedCrossRefGoogle Scholar
  130. 130.
    Krause TG, Hviid A, Koch A, Friborg J, Hjuler T, Wohlfahrt J, Olsen OR, Kristensen B, Melbye M (2003) BCG vaccination and risk of atopy. JAMA 289:1012–1015.PubMedCrossRefGoogle Scholar
  131. 131.
    Bremner SA, Carey IM, DeWilde S, Richards N, Maier WC, Hilton SR, Strachan DP, Cook DG (2005) Timing of routine immunisations and subsequent hay fever risk. Arch Dis Childhood 90:567–573.CrossRefGoogle Scholar
  132. 132.
    Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O'Toole S, Myint SH, Tyrrell DA (1995) Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. BMJ 310:1225–1229.PubMedGoogle Scholar
  133. 133.
    Johnston NW, Johnston SL, Norman GR, Dai J, Sears MR (2006) The September epidemic of asthma hospitalization: School children as disease vectors. J Allergy Clin Immunol 117:557–562.PubMedCrossRefGoogle Scholar
  134. 134.
    Nicholson KG, Kent J, Ireland DC (1993) Respiratory viruses and exacerbations of asthma in adults. BMJ 307:982–986.PubMedGoogle Scholar
  135. 135.
    Pearson RSB (1958) Natural history of asthma, Acta Allergol XII:277–294.Google Scholar
  136. 136.
    Gern JE, Rosenthal LA, Sorkness RL, Lemanske J (2005) Effects of viral respiratory infections on lung development and childhood asthma. J Allergy Clin Immunol 115:668–674.PubMedCrossRefGoogle Scholar
  137. 137.
    Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, Johnston SL (2002) Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 359:831–834.PubMedCrossRefGoogle Scholar
  138. 138.
    Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A (2002) Synergism between allergens and viruses and risk of hospital admission with asthma: case—control study [erratum appears in BMJ 2002;324(7346):1131]. BMJ 324:763.Google Scholar
  139. 139.
    Leonardi-Bee J, Pritchard D, Britton J; the Parasites in Asthma Collaboration (2006) Asthma and current intestinal parasite infection: systematic review and meta-analysis. Am J Respir Crit Care Med 174:514–523.PubMedCrossRefGoogle Scholar
  140. 140.
    Cooper PJ, Chico ME, Vaca MG, Moncayo AL, Bland JM, Mafla E, Sanchez F, Rodrigues LC, Strachan DP, Griffin GE Effect of albendazole treatments on the prevalence of atopy in children living in communities endemic for geohelminth parasites: a cluster-randomised trial. Lancet 367:1598–1603.Google Scholar
  141. 141.
    van der Biggelaar AH, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, Yazdanbaksh M (2000) Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356:1723–1727.PubMedCrossRefGoogle Scholar
  142. 142.
    Ober C,Hoffjan S (2006) Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 7:95–100.PubMedCrossRefGoogle Scholar
  143. 143.
    Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM (2002) Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 166:457–463.CrossRefGoogle Scholar
  144. 144.
    Kabesch M, Hoefler C, Carr D, Leupold W, Weiland SK, von ME (2004) Glutathione S transferase deficiency and passive smoking increase childhood asthma. Thorax 59(7):569–573.PubMedCrossRefGoogle Scholar
  145. 145.
    Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Estela del Rio-Navarro B, Hernandez-Avila M, London SJ (2004) Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax 59: 8–10.PubMedGoogle Scholar
  146. 146.
    Zock J-P, Heinrich J, Jarvis D, Verlato G, Norback D, Plana E, Sunyer J, Chinn S, Olivieri M, Soon A, Villani S, Ponzio M, Dahlman-Hoglund A, Svanes C, Luczynska C (2006) Distribution and determinants of house dust mite allergen in Europe: The European Community Respiratory Health Survey II. J Allergy Clin Immunol 118:682–690.PubMedCrossRefGoogle Scholar
  147. 147.
    Heinrich J, Bedada G, Zock J-P, Chinn S, Norback D, Olivieri M, Svanes C, Ponzio M, Verlato G, Villani S, Jarvis D, Luczynska C (2006) Cat allergen level: its determinants and relationship to specific IgE to cat across European centers. J Allergy Clin Immunol 118:674–681.PubMedCrossRefGoogle Scholar
  148. 148.
    Sporik RB, Holgate ST, Platts-Mills TAE, Cogswell JJ (1990) Exposure to house dust mite allergen (Der p 1) and the development of asthma in childhood. A prospective study. N Engl J Med 323:502–507.Google Scholar
  149. 149.
    Emberlin J, Savage M, Jones S (1993) Annual variations in grass pollen seasons in London 1961–1990; trends and forecast models. Clin Exp Allergy, 23:911–918.PubMedCrossRefGoogle Scholar
  150. 150.
    Seaton A, Godden DJ, Brown K (1994) Increase in asthma: a more toxic environment or a more susceptible population? Thorax 49:171–174.PubMedGoogle Scholar
  151. 151.
    Burr ML, Limb ES, Maguire MJ, Amarah L, Eldridge BA, Layzell JC, Merrett TG (1993) Infant feeding, wheezing, and allergy: a prospective study. Arch Dis Child 68:724–728.PubMedGoogle Scholar
  152. 152.
    Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, von ME, Wahn U (2000) Early exposure to house-dust mite and cat allergens and development of childhood asthma: S cohort study. Lancet 356:1392–1397.PubMedCrossRefGoogle Scholar
  153. 153.
    Marks GB, Mihrshahi S, Kemp AS, Tovey ER, Webb K, Almqvist C, Ampon RD, Crisafulli D, Belousova EG, Mellis CM, Peat JK, Leeder SR (2006) Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol 118:53–61.PubMedCrossRefGoogle Scholar
  154. 154.
    Torrent M, Sunyer J, Garcia R, Harris J, Iturriaga MV, Puig C, Vall O, Anto JM, Newman Taylor AJ, Cullinan P (2007) Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age. Am J Respir Crit Care Med 176:446–453.PubMedCrossRefGoogle Scholar
  155. 155.
    Gotzsche P, Johansen H, Schmidt L, Burr M (2004) House dust mite control measures for asthma. Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.Google Scholar
  156. 156.
    Kilburn S, Lasserson T, McKean M (2001) Pet allergen control measures for allergic asthma in children and adults. Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.Google Scholar
  157. 157.
    Khot A, Evans N, Lenney W (1983) Seasonal trends in childhood asthma in south east England. BMJ 287:1257–1258.PubMedGoogle Scholar
  158. 158.
    Marks GB, Burney P (1997) Diseases of the respiratory system. In: Charlton J, Murphy M (eds). The health of adult Britain 1841–1994. The Stationery Office, London, pp 93–113.Google Scholar
  159. 159.
    Weiss K (1990) Seasonal trends in US asthma hospitalisations and mortality. JAMA 263:2323–2328.PubMedCrossRefGoogle Scholar
  160. 160.
    Pollart SM, Reid MJ, Fling J, Chapman MD, Platts-Mills TAE (1988) Epidemiology of emergency room asthma in Northern California: association with IgE antibody to rye-grass pollen. J Allergy Clin Immunol 82:224–230.PubMedCrossRefGoogle Scholar
  161. 161.
    Pollart SM, Chapman MD, Fiocco GP, Rose G, Platts-Mills TAE (1989) Epidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits. J Allergy Clin Immunol 83:875–882.PubMedCrossRefGoogle Scholar
  162. 162.
    Sunyer J, Anto JM, Sabria J, Rodrigo MJ, Roca J, Morell F, Rodriguez-Roisin R, Codina R (1992) Risk factors of soybean epidemic asthma. The role of smoking and atopy. Am Rev Respir Dis 145:1098–1102.PubMedGoogle Scholar
  163. 163.
    Anto JM, Sunyer J, Reed CE, Sabria J, Martinez F, Morell F, Codina R, Rodriguez-Roisin R, Rodrigo MJ, Roca J (1993) Preventing asthma epidemics due to soybeans by dust-control measures. N Engl J Med 329:1760–1763.PubMedCrossRefGoogle Scholar
  164. 164.
    Figley KD, Elrod RH (1928) Endemic asthma due to castor bean dust. JAMA 90:79–82.Google Scholar
  165. 165.
    Mendes E, Cintra AU (1954) Collective asthma, simulation an epidemic, provoked by castor-bean dust. J Allergy 25:253–259PubMedCrossRefGoogle Scholar
  166. 166.
    Ordman D (1955)An outbreak of bronchial asthma in South Africa affecting more than 200 persons caused by castor bean dust from an oil processing factory. Int Arch Allergy Immunol 7:10–24.Google Scholar
  167. 167.
    Marks GB, Colquhoun JR, Girgis ST, Hjelmroos Koski M, Treloar ABA, Hansen P, Downs SH, Car NG (2001) Thunderstorms outflows preceding epidemics of asthma during spring and summer. Thorax 56:468–471.PubMedCrossRefGoogle Scholar
  168. 168.
    Newson R, Strachan D, Archibald E, Emberlin J, Hardaker P, Collier C (1998) Acute asthma epidemics, weather and pollen in England, 1987–1994. Eur Respir J 11:694–701.PubMedGoogle Scholar
  169. 169.
    Venables KM, Allitt U, Collier CG, Emberlin J, Greig JB, Hardaker PJ, Highham JH, Laing-Morton T, Maynard RL, Murray V, Strachan D, Tee RD (1997) Thunderstorm-related asthma—the epidemic of 24/25 June 1994. Clin Exp Allergy 27:725–736.PubMedGoogle Scholar
  170. 170.
    O'Hollaren M, Yunginger J, Offord K, et al (1991) Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 324:359–363.PubMedCrossRefGoogle Scholar
  171. 171.
    Bjorksten B, Suoniemi I (1981) Time and intensity of first pollen contacts and risk of subsequent pollen allergies. Acta Med Scand 209:299–303.PubMedGoogle Scholar
  172. 172.
    Bjorksten F, Suoniemi I, Koski V (1980) Neonatal birch-pollen contact and subsequent allergy to birch pollen. Clin Allergy 10:585–591.PubMedCrossRefGoogle Scholar
  173. 173.
    N. Aberg (1989) Birth season variation in asthma and allergic rhinitis. Clin Exp Allergy 19:643–648.PubMedCrossRefGoogle Scholar
  174. 174.
    Anderson HR, Bailey PA, Bland JM (1981) The effect of birth month on asthma, eczema, hayfever, respiratory symptoms, lung function, and hospital admissions for asthma. Int J Epidemiol 10:45–51.PubMedCrossRefGoogle Scholar
  175. 175.
    Morrison Smith J, Springett H (1979) Atopic disease and month of birth. Clin Allergy 9:153–157.CrossRefGoogle Scholar
  176. 176.
    Pearson DJ, Freed DJ, Taylor G. Respiratory allergy and month of birth. Clin. Allergy 7:29–34.Google Scholar
  177. 177.
    Reed C, Covallis MD (1958) The failure of antepartum or neonatal exposure to grass pollen to influence the later development of grass sensitivity. J Allergy Clin Immunol 29:300–301.Google Scholar
  178. 178.
    Tricon S, Willers S, Smit HA, Burney PG, Devereux G, Frew AJ, Halken S, Host A, Nelson M, Shaheen S, Warner JO, Calder PC (2006) Nutrition and allergic disease. Clin Exp Allergy Rev 6:117–188.CrossRefGoogle Scholar
  179. 179.
    Thien FCK, De Luca S, Woods R, Abramson MJ (2002) Dietary marine fatty acids (fish oil) for asthma in adults and children., Cochrane Database of Systematic Reviews, Issue 2. doi: 10.1002/14651858.CD001283.Google Scholar
  180. 180.
    Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, Britton J (2003) Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebocontrolled trial. Clin Exp Allergy 33:1355–1359.PubMedCrossRefGoogle Scholar
  181. 181.
    Pearson PJ, Lewis SA, Britton J, Fogarty A (2004) Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax 59(8):652–656.PubMedCrossRefGoogle Scholar
  182. 182.
    Shaheen SO, Hines M, Newson RB, Wheeler M, Herrick DR, Strachan DP, Jones RW, Burney PG, Henderson AJ (2007) Maternal testosterone in pregnancy and atopic outcomes in childhood. Allergy 62:25–32.PubMedCrossRefGoogle Scholar
  183. 183.
    Devereux G (2006) The increase in the prevalence of asthma and allergy: food for thought. Nat Rev Immunol 6:869–874.PubMedCrossRefGoogle Scholar
  184. 184.
    Shaheen SO, Newson RB, Henderson AJ, Emmett PM, Sherriff A, Cooke M;the ALSPAC Study Team (2004) Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Eur Respir J 24:292–297.PubMedCrossRefGoogle Scholar
  185. 185.
    Devereux G, McNeill G, Newman G, Turner S, Craig L, Martindale S, Helms P, Seaton A (2007) Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates. Clin Exp Allergy 37:1000–1008.PubMedCrossRefGoogle Scholar
  186. 186.
    Litonjua AA, Rifas-Shiman SL, Ly NP, Tantisira KG, Rich-Edwards JW, Camargo Jr CA, Weiss ST, Gillman MW, Gold DR (2006) Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr 84:903–911.PubMedGoogle Scholar
  187. 187.
    Martindale S, McNeill G, Devereux G, Campbell D, Russell G, Seaton A (2005) Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. Am J Respir Crit Care Med 171:121–128.PubMedCrossRefGoogle Scholar
  188. 188.
    Camargo Jr CA, Rifas-Shiman SL, Litonjua AA, Rich-Edwards JW, Weiss ST, Gold DR, Kleinman K, Gillman MW (2007) Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr 85:788–795.PubMedGoogle Scholar
  189. 189.
    Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, Martindale S, Helms PJ, Seaton A, Weiss ST (2007) Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 85:853–859.PubMedGoogle Scholar
  190. 190.
    Newson RB, Shaheen SO, Henderson AJ, Emmett PM, Sherriff A, Calder PC; the ALSPAC Study Team (2004) Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema. J Allergy Clin Immunol 114:531–537.PubMedCrossRefGoogle Scholar
  191. 191.
    Friedman NJ, Zeiger RS (2005) The role of breast-feeding in the development of allergies and asthma. J Allergy Clin Immunol 115:1238–1248.PubMedCrossRefGoogle Scholar
  192. 192.
    von Mutius E, Weiland S, Fritzsch C, Duhme H, Keil U, Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 351:862–866.Google Scholar
  193. 193.
    Becklake M, U. Lalloo U (1990) The ‘healthy smoker’: a phenomenon of health selection?, Respiration 57:137–144.PubMedGoogle Scholar
  194. 194.
    Jarvis D, Chinn S, Luczynska C, Burney P (1999) The association of smoking with sensitization to common environmental allergens: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 104(5):934–940.PubMedCrossRefGoogle Scholar
  195. 195.
    Marks GB, Salome CM, Woolcock A (1991) Asthma and allergy associated with occupational exposure to ispaghula and senna products in a pharmaceutical work force. Am Rev Respir Dis 144:1065–1069.PubMedGoogle Scholar
  196. 196.
    Park HS, Lee MK, Kim BO, Lee KJ, Roh JH, Moon YH, Hong CH (1991) Clinical and immunologic evaluations of reactive dye-exposed workers. J Allergy Clin Immunol 87:639–649.PubMedCrossRefGoogle Scholar
  197. 197.
    Zetterstrom O, Osterman K, Machado L, Johansson SG (1981) Another smoking hazard:raised serum IgE concentration and increased risk of occupational allergy. BMJ 283:1215–1217.PubMedCrossRefGoogle Scholar
  198. 198.
    Omenaas E, Bakke P, Elsayed S, Hanoa R, Gulsvik A (1994) Total and specific serum IgE levels in adults:relationship to sex,age and environmental factors. Clin Exp Allergy 24:530–539.PubMedCrossRefGoogle Scholar
  199. 199.
    B. Wuthrich, C. Schindler, T. C. Medici, J. P. Zellweger JP, Leuenberger P (1996) IgE levels, atopy markers and hay fever in relation to age, sex and smoking status in a normal adult Swiss population. SAPALDIA (Swiss Study on Air Pollution and Lung Diseases in Adults) Team. Int Arch Allergy Immunol 111:396–402.PubMedGoogle Scholar
  200. 200.
    Piipari R, Jaakkola JJK, Jaakkola N, Jaakkola MS (2004) Smoking and asthma in adults. Eur Respir J 24:734–739.PubMedCrossRefGoogle Scholar
  201. 201.
    Siroux V, Pin I, Oryszczyn MP, Le Moual N, Kauffmann F (2000) Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the genetics and environment of asthma. Eur Respir J 15:470–477.PubMedCrossRefGoogle Scholar
  202. 202.
    Chinn S, Jarvis D, Luczynska C, Ackermann-Liebrich U, Anto JM, Cerveri I, de Marco R, Gislason T, Heinrich J, Janson C, Kunzli N, Leynaert B, Neukirch F, Schouten J, Sunyer J, Svanes C, Wjst M, Burney P (2005) An increase in bronchial responsiveness is associated with continuing or restarting smoking. Am J Respir Crit Care Med 172:956–961.PubMedCrossRefGoogle Scholar
  203. 203.
    Cook DG, Strachan DP (1999) Health effects of passive smoking: summary of effects of parental smoking on the respiratory health of children and implications for research. Thorax 54:357–366.PubMedGoogle Scholar
  204. 204.
    Janson C, Chinn S, Jarvis D, Zock JP, Toren K, Burney P (2001) Effect of passive smoking on respiratory symptoms, bronchial responsiveness, lung function, and total serum IgE in the European Community Respiratory Health Survey: a cross-sectional study. Lancet 358:2103–2109.PubMedCrossRefGoogle Scholar
  205. 205.
    Forbes L (2005) Asthma and atopy: endocrine or metabolic conditions? Thorax 60:793–794.PubMedCrossRefGoogle Scholar
  206. 206.
    Svanes C, Gomez Real F, Gislason T, Janson C, Jogi R, Norrman E, Toren K, Omenaas E (2005) Association of asthma and hayfever with irregular menstruation. Thorax 60:445–450.PubMedCrossRefGoogle Scholar
  207. 207.
    Philpott CM, El-Alami M, Murty GE (2004) The effect of the steroid sex hormones on the nasal airway during the normal menstrual cycle1. Clin Otolaryngol 29:138–142.PubMedCrossRefGoogle Scholar
  208. 208.
    Ishizaki T, Koizumi K, Ikemori R, Ishiyama Y, Kushibiki E (1987) Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy 58:265–270.PubMedGoogle Scholar
  209. 209.
    Wyler C, Braun-Fahrlander C, Kunzli N, Schindler C, ckermann-Liebrich U, Perruchoud AP, Leuenberger P, Wuthrich B (2000) Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology 11:450–456.PubMedCrossRefGoogle Scholar
  210. 210.
    Hirsch T, Weiland SK, von Mutius E, Safeca AF, Grafe H, Csaplovics E, Duhme H, Keil U, Leupold W (1999) Inner city air pollution and respiratory health and atopy in children. Eur Respir J 14:669–677.PubMedCrossRefGoogle Scholar
  211. 211.
    Kramer U, Koch T, Ranft U, Ring J, Behrendt H (2000) Traffic-related air pollution is associated with atopy in children living in urban areas. Epidemiology 11:64–70.PubMedCrossRefGoogle Scholar
  212. 212.
    Penard-Morand C, Charpin D, Raherison C, Kopferschmitt C, Caillaud D, Lavaud F, nnesi-Maesano I (2005) Long-term exposure to background air pollution related to respiratory and allergic health in schoolchildren. Clin Exp Allergy 35:1279–1287.CrossRefGoogle Scholar
  213. 213.
    McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J (2006) Traffic, susceptibility, and childhood asthma. Environ Health Perspect 114(5):766–772.PubMedCrossRefGoogle Scholar
  214. 214.
    Modig L, Jarvholm B, Ronnmark E, Nystrom L, Lundback B, Andersson C, Forsberg B (2006) Vehicle exhaust exposure in an incident case—control study of adult asthma. Eur Respir J 28:75–81.PubMedCrossRefGoogle Scholar
  215. 215.
    Hajat S, Haines A, Goubet SA, Atkinson RW, Anderson HR (1999) Association of air pollution with daily GP consultations for asthma and other lower respiratory conditions in London. Thorax 54:597–605.PubMedGoogle Scholar
  216. 216.
    Atkinson RW, Bremner SA, Anderson HR, Strachan DP, Bland JM, de Leon AP (1999) Short-term associations between emergency hospital admissions for respiratory and cardiovascular disease and outdoor air pollution in London. Arch Environ Health 54:398–411.PubMedGoogle Scholar
  217. 217.
    Anderson HR, Ponce de Leon A, Bland JM, Bower J, Emberlin J, Strachan D (1998) Air pollution, pollens, and daily admission for asthma in London 1987–92. Thorax 53:842–848.PubMedGoogle Scholar
  218. 218.
    Sunyer J, Spix C, Quenel P, Ponce-de-Leon A, Ponka A, Barumandzadeh T, Touloumi G, Bacharova L, Wojtyniak B, Vonk J, Bisanti L, Schwartz J, Katsouyanni K (1997) Urban air pollution and emergency admissions for asthma in four European cities: the APHEA Project. Thorax 52:760–765.PubMedCrossRefGoogle Scholar
  219. 219.
    Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, Boumghar A, Forastiere F, Forsberg B, Touloumi G, Schwartz J, Katsouyanni K (2001) Acute effects of particulate air pollution on respiratory admissions—Results from APHEA 2 project. Am J Respir Crit Care Med 164:1860–1866.PubMedGoogle Scholar
  220. 220.
    Roemer W, Hoek G, Brunekreef B, Haluszka J, Kalandidi A, Pekkanen J; for the PEACE project (1998) Daily variations in air pollution and respiratory health in a multicentre study: the PEACE project. Eur Respir J 12:1354–1361.PubMedCrossRefGoogle Scholar
  221. 221.
    Fry J (1951) Effects of a severe fog on a general practice. Lancet 235–236.Google Scholar
  222. 222.
    Wichmann HE, Mueller W, Allhof P, Beckmann M, Bocter N, Csicsaky MJ, Jung M, Molik B, Schoeneberg G (1989) Health effects during a smog episode in West Germany in 1985. Environ Health Perspect 79:89–99.PubMedCrossRefGoogle Scholar
  223. 223.
    Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM (2001) Respiratory effects of relocating to areas of differing air pollution levels. Am J Respir Crit Care Med 164(11):2067–2072.PubMedGoogle Scholar
  224. 224.
    Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J (2004) The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med, 351:1057–1067.PubMedCrossRefGoogle Scholar
  225. 225.
    McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM (2002) Asthma in exercising children exposed to ozone: a cohort study. [erratum appears in Lancet 2002 Mar 9;359(9309):896]. Lancet 359:386–391.PubMedCrossRefGoogle Scholar
  226. 226.
    Bergamaschi E, de Palma G, Mozzoni P, Vanni S, Vettori M, Broeckaert F, Bernard A, Mutti A (2001) Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects. Am J Respir Crit Care Med 163:1426–1431.PubMedGoogle Scholar
  227. 227.
    Romieu I, Ramirez-Aguilar M, Sienra-Monge JJ, Moreno-Macias H, del Rio-Navarro BE, David G, Marzec J, Hernandez-Avila M, London S (2006) GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J 28:953–959.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  • Deborah Jarvis
    • 1
  • Seif Shaheen
    • 1
  • Peter Burney
    • 1
  1. 1.Respiratory Epidemiology and Public Health GroupNational Heart and Lung InstituteImperial College London

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