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Impact of Tobacco Smoke on Asthma and Allergic Disease

  • Eric Livingston
  • Neil C. Thomson
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

The prevalence of asthma and other atopic diseases are rising. Genetic factors are unable to explain the increase in prevalence over the last few decades. It seems very likely that there is a strong environmental influence on the expression of allergic diseases [1]. These exposures may occur in childhood or adult life but environmental exposure during pregnancy may also dictate patterns of disease in later life. The risk factors that might have contributed to this increase include active and passive tobacco smoking, which are on the rise in certain age groups and in females. Allergic conditions share numerous characteristics including the production of IgE antibodies in response to allergens, an impaired balance between cytokines of the Th1 and Th2 lymphocytes, a positive family history of atopic diseases and sometimes the expression of several atopic conditions [1]. In this chapter, the effect of exposure to environmental tobacco smoke (ETS) and active smoking on the development and clinical manifestations of asthma and other allergic conditions will be reviewed.

Keywords

Smoking Cessation Allergic Rhinitis Allergic Disease Airway Inflammation Allergy Clin Immunol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Von Mutius E (2000) The environmental predictors of allergic disease. J Allergy Clin Immunol 105:9–19.CrossRefGoogle Scholar
  2. 2.
    CDC (2006) Fact Sheet: Adult cigarette smoking in the United States: current estimates. Smoking and Tobacco Use.Google Scholar
  3. 3.
    Walker A, O'Brien M, Traynor J, Fox K, Goddard E, Foster K (2002) Living in Britain: Results from the 2001 General Household Survey. Office for National Statistics, London. 115–121.Google Scholar
  4. 4.
    Livingston E, Thomson N, Chalmers G (2005) Impact of smoking on asthma therapy. Drugs 65:1521–1536.PubMedCrossRefGoogle Scholar
  5. 5.
    Thomson N, Chaudhuri R, Livingston E (2004) Asthma and cigarette smoking. Eur Respir J 24:822–833.PubMedCrossRefGoogle Scholar
  6. 6.
    Nelson E (2001) The miseries of passive smoking. Hum Exp Toxicol 20:61–83.PubMedCrossRefGoogle Scholar
  7. 7.
    Swauger J, Steichen T, Murphy P, Kinsler S (2002) An analysis of the mainstream smoke chemistry of sample in the US cigarette market acquired between 1995 and 2000. Regul Toxicol Pharmacol 35:142–156.PubMedCrossRefGoogle Scholar
  8. 8.
    Hoffmann D, Wydner D (1986) Chemical constituents and bioactivity of tobacco smoke. IARC Sci Publ 74:145–165.PubMedGoogle Scholar
  9. 9.
    Djukanovic R, Roche W, Wilson J, et al (1990) Mucosal inflammation in asthma. Am Rev Resp Dis 142:434–457.PubMedGoogle Scholar
  10. 10.
    Busse W, Lemanske R (2001) Asthma. N Engl J Med 344(5):350–362.PubMedCrossRefGoogle Scholar
  11. 11.
    Bousquet J, Jeffery P, Busse W, Johnston M, Vignola A (2000) Asthma: From bronchocon-striction to airways inflammation and remodelling. Am J Respir Crit Care Med 161:1720–1745.PubMedGoogle Scholar
  12. 12.
    Brightling C, Bradding P, Symon F, Holgate S, Wardlaw A, Pavord I (2002) Mast cell infiltra tion of airway smooth muscle. N Engl J Med 346:1699–1705.PubMedCrossRefGoogle Scholar
  13. 13.
    Carroll N, Cooke C, James A (1997) The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J 10:292–300.PubMedCrossRefGoogle Scholar
  14. 14.
    Kraft M, Djukanovic R, Wilson S, Holgate S, Martin R (1996) Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 154:1505–1510.PubMedGoogle Scholar
  15. 15.
    Laitinen, L, Laitinen A, Haahtela T (1993) Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Resp Dis 147:697–704.PubMedGoogle Scholar
  16. 16.
    Jeffery P, Wardlaw A, Nelson F, Collins J, Kay A (1989) Bronchial biopsies in asthma: an ultrastructural, quantatative study and correlation with hyperreactivity. Am Rev Resp Dis 140:1745–1753.PubMedGoogle Scholar
  17. 17.
    Vignola A, Chanez P, Campbell A, et al (1998) Airway inflammation in mild, intermittent, and persistent asthma. Am J Respir Crit Care Med 157:403–409.PubMedGoogle Scholar
  18. 18.
    Bousquet J, Chanez P, Lacoste P, et al (1990) Eosinophilic inflammation in asthma. N Engl J Med 323:1033–1039.PubMedGoogle Scholar
  19. 19.
    Gleich G (1990) The eosinophil and bronchial asthma. J Allergy Clin Immunol 85:422–436.PubMedCrossRefGoogle Scholar
  20. 20.
    Barnes P, Rodger I, Thomson N (1998) Asthma: basic mechanisms and clinical management, 3rd edn. Academic Press, San Diego, CA.Google Scholar
  21. 21.
    Corrigan C, Brown P, Barnes N, Szefler S, Tsai J, Frew A, Kay A (1991) Glucocorticoid resistance in chronic asthma: Glucocorticoid pharmacokinetics, glucocorticoid receptor char acteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am Rev Respir Dis 144:1016–1025.PubMedGoogle Scholar
  22. 22.
    Wasserman S (1994) Mast cells and airway inflammation in asthma. Am J Respir Crit Care Med 150:S39–S41.PubMedGoogle Scholar
  23. 23.
    Keatings V, Evans D, O'Connor B, Barnes P (1997) Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. Thorax 52:372–374.PubMedGoogle Scholar
  24. 24.
    Kuschner W, D'Alessandro A, Wong H, Blanc P (1996) Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J 9:1989–1994.PubMedCrossRefGoogle Scholar
  25. 25.
    Roth M, Arora A, Barsky S, Kleerup E, Simmons M, Tashkin D (1998) Airway inflammation in young marijuana and tobacco smokers. Am J Respir Crit Care Med 157:928–937.PubMedGoogle Scholar
  26. 26.
    Jeffery P (1998) Structural and inflammatory changes in COPD: a comparison with asthma. Thorax 53:129–136.PubMedGoogle Scholar
  27. 27.
    Saetta M, Turato G, Maestrelli P, et al (2001) Cellular and structural basis of chronic obstruc tive pulmonary disease. Am J respir Crit Care Med 163:1304–1309.PubMedGoogle Scholar
  28. 28.
    Chalmers G, MacLeod K, Thomson L, Little S, McSharry C, Thomson N (2001) Smoking and airway inflammation in patients with mild asthma. Chest 120(6):1917–1922.PubMedCrossRefGoogle Scholar
  29. 29.
    Boulet L, Lemiere C, Archambault F, Carrier G, Descary M, Deschesnes F (2006) Smoking and Asthma: Clinical and radiologic features, lung function and airway inflammation. Chest 129(3):661–668.PubMedCrossRefGoogle Scholar
  30. 30.
    Lazarus S, Chinchilli V, Rollings N, Boushey H, Cherniak R, Craig T, Deykin A, DiMango E, et al (2007) Smoking affects the response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med 175:783–790.PubMedCrossRefGoogle Scholar
  31. 31.
    Livingston E, Chaudhuri R, McMahon A, Fraser I, McSharry C, Thomson N (2007) Systemic sensitivity to corticosteroids in smokers with asthma. Eur Respir J 29:64–71.PubMedCrossRefGoogle Scholar
  32. 32.
    Sopori M, Kozak W (1998) Immunomodulatory effects of cigarette smoke. J Neuroimmunol 83:148–156.PubMedCrossRefGoogle Scholar
  33. 33.
    Tsoumakidou M, Elston W, Zhu J, et al (2007) Cigarette smoking alters bronchial mucosal immunity in asthma. Am J Respir Crit Care Med 175:919–925.PubMedCrossRefGoogle Scholar
  34. 34.
    Sjaheim S, Kongerud J, Bjortuft O, Drablos P, Malterud D, Halstensen T (2006) Reduced bronchial CD4 + T-cell density in smokers with occupational asthma. Eur Respir J 28(6):1138–1144.PubMedCrossRefGoogle Scholar
  35. 35.
    Carroll N, Perry S, Karkhanis A, et al (2000) The airway longitudinal elastic fiber network and mucosal folding in patients with asthma. Am J Respir Crit Care Med 161:244–248.PubMedGoogle Scholar
  36. 36.
    Bergeron C, Boulet L, Page N, et al (2007) Influence of cigarette smoke on the arginine pathway in asthmatic airways: Increased expression of arginase I. J Allergy Clin Immunol 119(2):391–397.PubMedCrossRefGoogle Scholar
  37. 37.
    Rennard S, Daughton D, Fujita J, Oehlerking M, Dobson J, Stahl M, Robbins R, Thompson A (1990) Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers. Eur Respir J 3:752–759.PubMedGoogle Scholar
  38. 38.
    Turato G, Di Stefano A, Maestrelli P, Mapp C, Ruggieri M, Roggeri A, Fabbri L (1995) Effect of smoking cessation on airway inflammation in chronic bronchitis. Am J Respir Crit Care Med 152:1262–1267.PubMedGoogle Scholar
  39. 39.
    Willemse B, ten Hacken N, Rutgers B, Lesman-Leegte I, Timens W, Postma D (2004) Smoking cessation improves both direct and indirect airway hyperresponsiveness in COPD. Eur Respir J 24:391–394.PubMedCrossRefGoogle Scholar
  40. 40.
    Domagala-Kulawik J, Maskey-Warzechowska M, Kraszewska I, Chazan R (2003) The cel lular composition and macrophage phenotype in induced sputum in smokers and ex-smokers. Chest 123:1054–1059.PubMedCrossRefGoogle Scholar
  41. 41.
    Chaudhuri R, Livingston E, McMahon A, Lafferty J, Fraser I, Spears M, McSharry C, Thomson N (2006) Efects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med 174:127–133.PubMedCrossRefGoogle Scholar
  42. 42.
    McKay A, Komai-Koma M, MacLeod K, et al (2001) Interleukin-18 levels in induced sputum are reduced in both asthmatic and normal smokers. Thorax 56:iii81.Google Scholar
  43. 43.
    Rasmussen F, Lambrechtsen J, Hansen H, Hansen N (2000) Impact of airway lability, atopy and tobacco smoking in the development of asthma-like symptoms in asymptomatic teenagers. Chest 117:1–9.CrossRefGoogle Scholar
  44. 44.
    Lam T, Chung S, Betson C, Wong C, Hedley A (1998) Respiratory symproms due to active and passive smoking in junior secondary school students in Hong Kong. Int J Epidemiol 27(1):41–48.PubMedCrossRefGoogle Scholar
  45. 45.
    Toren K, Hermansson B (1999) Incidence rate of adult-onset asthma in relation to age, sex, atopy and smoking: a Swedish population based study of 15813 adults. Int J Tuberc Lung Dis 3:192–197.PubMedGoogle Scholar
  46. 46.
    Plaschke P, Janson C, Norrman E, Bjornsson E, Ellbjar S, Jarvholm B (2000) Onset and remis sion of allergic rhinitis and asthma and the relationship with atopic sensitisationa and smoking. Am J Respir Crit Care Med 162:920–924.PubMedGoogle Scholar
  47. 47.
    Kim Y, Kim S, Tak Y, et al (2002) High prevalence of asthma and active smoking effect among the elderly. Exp Allergy 32:1706–1712.CrossRefGoogle Scholar
  48. 48.
    Althuis M, Sexton M, Prybylski D (1999) Cigarette smoking and asthma symptom severity among adult asthmatics. J Asthma 36(3):257–264.PubMedCrossRefGoogle Scholar
  49. 49.
    Siroux V, Pin I, Oryszcyn MP, Le Moual N, Kauffmann F (2000) Relationships of active smoking to asthma and asthma severity in the EGEA study. Eur Respir J 15:470–477.PubMedCrossRefGoogle Scholar
  50. 50.
    Silverman R, Boudreaux E, Woodruff P, Clark S, Camargo CJ (2003) Cigarette smoke among asthmatic subjects presenting to 64 emergency departments. Chest 123:1472–1479.PubMedCrossRefGoogle Scholar
  51. 51.
    Sippel J, Pedula K, Vollmer W, et al (1999) Association of smoking with hospital based care and quality of life in patients with obstructive lung disease. Chest 115:691–696.PubMedCrossRefGoogle Scholar
  52. 52.
    Turner M, Noertjojo K, Vedal S, et al (1998) Risk factors for near fatal asthma: a case—control study in hospitalised patients with asthma. Am J Respir Crit Care Med 157:1804–1809.PubMedGoogle Scholar
  53. 53.
    Walsh L, Wong C, Cooper S, Guhan A, Pringle M, Tattersfield A (1999) Morbidity in asthma in relation to regular treatment: a community based study. Thorax 54:296–300.PubMedGoogle Scholar
  54. 54.
    Apostol G, Jacobs G, Tsai A, et al (2002) Early life factors contribute to the decrease in lung function between ages of 18–40. Am J Respir Crit Care Med 166:166–172.PubMedCrossRefGoogle Scholar
  55. 55.
    Prescott E, Lange P, Vestbo J; ATCCHS group (1997) Effect of gender on hospital admissions for asthma and prevalence of self reported asthma: a prospective study based on a sample of the general population. Thorax 52:287–289.PubMedGoogle Scholar
  56. 56.
    Ryan G, Musk A, Perera D, Stock H, Knight J, Hobbs M (1991) Risk factors for death in patients admitted to hospital with asthma: a follow-up study. Aust N Z J Med 21:681–685.PubMedGoogle Scholar
  57. 57.
    Mitchell I, Tough S, Semple L, Green F, Hessel P (2002) Near fatal asthma: a population based study of risk factors. Chest 121:1407–1413.PubMedCrossRefGoogle Scholar
  58. 58.
    LeSon S, Gershwin E (1996) Risk factors for asthmatic patients requiring intubation.III. Observations in young adults. J Asthma 33:27–35.Google Scholar
  59. 59.
    Marquette C Saulnier F, Leroy O, Wallaert B, Chopin C, Demarcq J, Durocher A,Tonnel A (1992) Long term prognosis of near fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventillation for a near fatal asthma attack. Am Rev Resp Dis 146:76–81.Google Scholar
  60. 60.
    Lange P, Parner J, Vestbo J, Schnohr P, Jensen G (1998) A 15 year follow-up study of ventilatory function in adults with asthma. N Engl J Med 339:1194–1200.PubMedCrossRefGoogle Scholar
  61. 61.
    O'Connor G, Weiss S, Tager I, Speitzer F (1987) The effect of passive smoking on pulmonary function and non-specific bronchial responsiveness in a population based sample of children and young adults. Am Rev Resp Dis 135:800–804.PubMedGoogle Scholar
  62. 62.
    Ulrik C, Lange P (1994) Decline in lung function an adults with bronchial asthma. Am J Respir Crit Care Med 150:629–634.PubMedGoogle Scholar
  63. 63.
    FDA (1979) Drug effects can go up in smoke. FDA Consumer March:17–18.Google Scholar
  64. 64.
    Zevin S, Benowitz N (1999) Drug interactions with Tobacco smoking: An update. Clin Pharmacokinet 36:425–438.PubMedCrossRefGoogle Scholar
  65. 65.
    GINA (2006) Global Initiative for Asthma: Global strategy for asthma management and pre vention. NHLBI/WHO Workshop report: NIH Publication No. 02-659.Google Scholar
  66. 66.
    Chaudhuri R, Livingston E, McMahon A, Thomson L, Borland W, Thomson N (2003) Cigarette smoking impairs the therapeutic response to oral corticosteroids. Am J Respir Crit Care Med 168:1308–1311.PubMedCrossRefGoogle Scholar
  67. 67.
    Chalmers G, MacLeod K, Little S, Thomson L, McSharry C, Thomson N (2002) Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 57:1–5.CrossRefGoogle Scholar
  68. 68.
    Pedersen B, Dahl R, Karlstrom R, Peterson C, Venge P (1996) Eosinophil and neutrophil activity in asthma in one-year trial with inhaled budesonide. Am J Respir Crit Care Med 153:1519–1529.PubMedGoogle Scholar
  69. 69.
    Tomlinson J, McMahon A, Chaudhuri R, Thompson J, Wood S, Thomson N (2005) Efficacy of low and high dose inhaled corticosteroids in smokers versus non-smokers with mild asthma. Thorax 60(4):282–287.PubMedCrossRefGoogle Scholar
  70. 70.
    Thomson N, Chaudhuri R, E. Livingston E (2003) Active cigarette smoking and asthma. Clin Exp Allergy 33:1471–1475.PubMedCrossRefGoogle Scholar
  71. 71.
    Farrell R, Kelleher D (2003) Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol 178:339–346.PubMedCrossRefGoogle Scholar
  72. 72.
    Barnes P, Adcock I (2003) How do corticosteroids work in asthma?. Ann Intern Med 139:359–370.PubMedGoogle Scholar
  73. 73.
    Kino T, Chrousos G (2002) Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: Multifactorial states of clinical importance. J Allergy Clin Immunol 109:609–613.PubMedCrossRefGoogle Scholar
  74. 74.
    Leung D, Bloom D (2003) Update on glucocorticoid action and resistance. J Allergy Clin Immunol 111(1):3–22.PubMedCrossRefGoogle Scholar
  75. 75.
    Schaaf M, Cidlowski J (2003) Molecular mechanisms of glucocorticoid action and resistance. J Ster Biochem Mol Biol 83:37–48.CrossRefGoogle Scholar
  76. 76.
    Rose J, Yurchak A, Meikle A, Jusko W (1981) Effect of smoking on prednisone, prednisolone, and dexamethasone. J Pharmacokinet Biopharm 9:1–14.PubMedCrossRefGoogle Scholar
  77. 77.
    Floreani A, Rennard S (1999) The role of cigarette smoke in the pathogenesis of asthma and as a trigger for acute symptoms. Curr Opin Pulm Med 5(1):38–46.PubMedCrossRefGoogle Scholar
  78. 78.
    Holt P (1987) Immune and inflammatory function in cigarette smokers. Thorax 42:241–249.PubMedGoogle Scholar
  79. 79.
    Green R, Brightling C, Woltmann G, Parker D, Wardlaw A, Pavord I (2002) Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 57:875–879.PubMedCrossRefGoogle Scholar
  80. 80.
    Ito K, Caramori G, Lim S, Oates T, Chung K, Barnes PJ, Adcock I (2002) Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 166(3):392–396.PubMedCrossRefGoogle Scholar
  81. 81.
    Ito K, Lim S, Caramori G, Chung K, Barnes P, Adcock I (2001) Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 15(6):1110–1112.PubMedGoogle Scholar
  82. 82.
    Hollenberg S, Weinberger C, Ong E, Cerelli G, Oro A, Lebo R, Thompson E, Rosenfeld M, Evans R (1985) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318:635–641.PubMedCrossRefGoogle Scholar
  83. 83.
    Hamid Q, Wenzel S, Hauk P, Tsicopoulos A, Wallaert B, Lafitte J, Chrousos G, Szefler S, Leung D (1999) Increased glucocorticoid receptor β in the airway cells of glucocrticoid-insensitive asthma. Am J Respir Crit Care Med 159:1600–1604.PubMedGoogle Scholar
  84. 84.
    Leung D, Hamid Q, Vottero A, Szefler S, Surs W, Minshall E, Chrousos G, Klemm D (1997) Association of Glucocorticoid Insensitivity with Increased Expression of Glucocortocoid Receptor β. J Exp Med 186(9):1567–1574.PubMedCrossRefGoogle Scholar
  85. 85.
    Sousa A, Lane S, Cidlowski J, Staynov D, Lee T (2000) Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform. J Allergy Clin Immunol 105:943–950.PubMedCrossRefGoogle Scholar
  86. 86.
    Pujols L, Mullol J, Perez M, Roca-Ferrer J, Juan M, Xaubet A, Cidlowski J, Picado C (2001) Expression of the human glucocorticoid receptor a and b isoforms in human respi ratory epithelial cells and their regulation by dexamethasone. Am J Respir Cell Mol Biol 24:49–57.PubMedGoogle Scholar
  87. 87.
    Livingston E, Darroch C, Chaudhuri R, McPhee I, McMahon A, SMacKenzie S, Thomson N (2004) Glucocorticoid receptor a:b ratio in blood mononuclear cells is reduced in cigarette smokers. J Allergy Clin Immunol 114:1475–1478.PubMedCrossRefGoogle Scholar
  88. 88.
    Strickland I, Kisich K, Hauk P, Vottero A, Chrousos G, Klemm D, Leung D (2001) High constitutive glucocorticoid receptor b in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med 193(5):585–593.CrossRefGoogle Scholar
  89. 89.
    Webster J, Oakley R, Jewell C, Cidlowski J (2001) Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci 98(12):6865–6870.PubMedCrossRefGoogle Scholar
  90. 90.
    Sher R, Leung D, Surs W, Kam J, Zieg A, Kamada A, Szefler S (1994) Steroid resistant asthma: Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 93:33–39.PubMedCrossRefGoogle Scholar
  91. 91.
    Gaki E, Papatheodorou G, Ischaki E, Grammenou V, Papa I, Loukides S (2007) Leukotriene E4 in urine in patients with asthma and COPD: the effect of smoking habit. Respir Med 101:826–832.PubMedCrossRefGoogle Scholar
  92. 92.
    Fauler J, Frolich J (1997) Cigarette smoking stimulates cysteinyl leukotriene production in man. Eur J Clin Invest 27:43–47.PubMedCrossRefGoogle Scholar
  93. 93.
    Hunt S Jusko W, Yurchak A (1976) Effect of smoking on theophylline disposition. Clin Pharmacol Ther 19:546–551.PubMedGoogle Scholar
  94. 94.
    Powell J, Thiercelin J, Vozeh S, et al (1977) The influence of cigarette smoking and sex on theophylline disposition. Am Rev Resp Dis 116:17–23.PubMedGoogle Scholar
  95. 95.
    Lee B, Benowitz N, III Jacob P (1987) Cigarette abstinence, nicotine gum, and theophylline disposition. Ann Intern Med 106:553–555.PubMedGoogle Scholar
  96. 96.
    dkk fgk, Thomson, N. (2007) Smokers with asthma: What are the management options?. Am J Respir Crit Care Med 175:749–750.PubMedCrossRefGoogle Scholar
  97. 97.
    Lange P, Scharling H, Ulrik C, Vestbo J (2006) Inhaled corticosteroids and decline in lung function in community residents with asthma. Thorax 61:100–104.PubMedCrossRefGoogle Scholar
  98. 98.
    Dijkstra A, Vonk J, Jongepier H, Koppelman G, Schouten J, ten Hacken N, Timens W, Postma D (2006) Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex. Thorax 61:105–110.PubMedCrossRefGoogle Scholar
  99. 99.
    Tonnesen P, Pisinger C, Hvidberg S, Wennike P, Bremann L, Westin A, Thomsen C, Nilsson F (2005) Effects of smoking cessation and reduction in asthmatics. Nicotine Tob Res 7:139–148.PubMedCrossRefGoogle Scholar
  100. 100.
    Eisner, M, Klein J, Hammond S, Koren G, Lactao G, Iribarren C (2005) Directly measured second hand smoke exposure and asthma health outcomes. Thorax 60:814–821.PubMedCrossRefGoogle Scholar
  101. 101.
    Dhar P (2004) Measuring tobacco smoke exposure: quantifying nicotine/cotinine concentra tion in biological samples by colorimetry, chromatography and immunoassay methods. J Pharmaceut Biomed Anal 36:155–168.CrossRefGoogle Scholar
  102. 102.
    Al-Delaimy W, Crane J, Woodward A (2002) Is the hair nicotine level a more accurate biomarker of environmental tobacco smoke exposure than urine cotinine?. J Epidemiol Community Health 56:66–71.PubMedCrossRefGoogle Scholar
  103. 103.
    Report of the Surgeon General (2006) The health consequences of involuntary exposure to tobacco smoke. US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health.Google Scholar
  104. 104.
    Pirkle J, Bernert J, Caudill S, Sosnoff C, Pechacek T (2006) Trends in the exposure of non-smokers in the US population to secondhand smoke. Environ Health Perspect 114(6):853–858.PubMedCrossRefGoogle Scholar
  105. 105.
    The National Survey on Environmental Management of Asthma and Children's Exposure to Environmental Tobacco Smoke (NSEMA/CEE). Fact Sheet: US Environmental Protection Agency (2004).Google Scholar
  106. 106.
    Janson C, Kunzli N, de Marco R, Chinn S, Jarvis D, Svanes C, Heinrich J, Jogi R, Gislason T, Sunyer J, Ackermann-Liebrich U, Anto J, Cerveri I, Kerhof M, Leynaert B, Lucynska C, Neukirch F, Vermeire P, Wjst M, Burney P (2006) Changes in active and passive smoking in the European Community Respiratory Health Study. Eur Respir J 27:517–524.PubMedCrossRefGoogle Scholar
  107. 107.
    Yun S, Chanetsa F, Kelsey A, Zhu B-P (2006) Active and passive smoking among asthmatic Missourians: Implications for health education. Preventive Medicine 42:286–290.PubMedCrossRefGoogle Scholar
  108. 108.
    Maier W, Arrighi H, Morray B, Llewellyn C, Redding G (1997) Indoor risks for asthma and wheezing among Seattle school children. Environ Health Perspect 105(2):208–214.PubMedCrossRefGoogle Scholar
  109. 109.
    Anarella J, Roohan P, Balistreri E, Gesten F (2004) A survey of medicaid recipients with asthma: Perceptions of self-management, access and care. Chest 125:1359–1367.PubMedCrossRefGoogle Scholar
  110. 110.
    Strachan D, Cook D (1998) Parental smoking and childhood asthma: Longitudinal and case-control studies. Thorax 53:204–212.PubMedGoogle Scholar
  111. 111.
    Cook D, Strachan D (1997) Health effects of passive smoking: 3. Parental smoking and prevalence of respiratory symptoms and asthma in school age children. Thorax 52(12):1081–1094.PubMedCrossRefGoogle Scholar
  112. 112.
    Cook D, Strachan D (1999) Summary of effects of parental smoking on the respiratory health of children and implications for research. Thorax 54:357–366.PubMedGoogle Scholar
  113. 113.
    Agency, C. E. P (2006) Proposed Identification of Environmental Tobacco Smoke as Toxic Air Contaminant. Part B: Health Effects. Sacremento (CA): California Environmental Protection Agency, Office of Environmental Health Hazard Assessment.Google Scholar
  114. 114.
    Jaakkola J, Kosheleva A, Katsnelson B, Kuzmin S, Privalova L, Spengler J (2006) Prenatal and postnatal tobacco smoke exposure and respiratory health in Russian children. Respir Res 7(1):48.PubMedCrossRefGoogle Scholar
  115. 115.
    Lannero E, Wickman M, Pershagen G, Nordvall L (2006) Maternal smoking during preg nancy increases the risk of recurrent wheezing during the first years of life (BASME). Respir Res 7(1):3.PubMedCrossRefGoogle Scholar
  116. 116.
    Lewis S, Antoniak M, Venn A, Davies L, Goodwin A, Salfield N, Britton J, Fogarty A (2005) Secondhand ssmoke, dietary fruit intake, road traffic exposures, and the prevalence of asthma: A cross-sectional study in young children. Am J Epidemiol 161:406–411.PubMedCrossRefGoogle Scholar
  117. 117.
    Li Y-F, Langholz B, Salam M, Gilliland F (2005) Maternal and grandmaternal smoking pat terns are associated with early childhood asthma. Chest 127:1232–1241.PubMedCrossRefGoogle Scholar
  118. 118.
    Skorge T, Eagan T, Eide G, Gulsvik A, Bakke P (2005) The adult incidence of asthma and respiratory symptoms by passive smoking in utero or in childhood. Am J Respir Crit Care Med 172:61–66.PubMedCrossRefGoogle Scholar
  119. 119.
    Menzies D, Nair A, Williamson P, et al (2006) Respiratory symptoms, pulmonary function, and markers of inflammation among bar workers before and after a legislative ban on smok ing in public places. JAMA 296(14):1742–1748.PubMedCrossRefGoogle Scholar
  120. 120.
    Halterman J, Szilagyi P, Yoos H, Conn K, Kaczorowski J, Holzhauer R, Lauver S, Neely T, Callahan P, McConnochie K (2004) Benefits of a school-based asthma treatment program in the absence of secondhand smoke exposure: results of a randomized clinical Trial. Arch Pediatr Adolesc Med 158:460–467.PubMedCrossRefGoogle Scholar
  121. 121.
    Kurisu Matsunga S, Plezia P, Karol M, Katz M, Camilli A, Benowitz N (1989) Effects of passive smoking on theophylline clearance. Clin Pharmacol Ther 46:399–407.Google Scholar
  122. 122.
    Casto D, Schnapf B, Clotz M (1990) Lack of effect of short-term passive smoking on the metabolic disposition of theophylline. Eur J Clin Pharmacol 39:399–402.PubMedCrossRefGoogle Scholar
  123. 123.
    Oryszczyn M, Annesi-Maesano I, Neukirch F, Dore M, Kauffman H (1991) Relationships of total IgE level, skin prick test response, and smoking habits. Ann Allergy 67:355–358.PubMedGoogle Scholar
  124. 124.
    Oryszczyn M, Annesi-Maesano I, Charpin D, Paty E, Maccario J, Kauffman H (2000) Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). Am J Respir Crit Care Med 161:1241–1246.PubMedGoogle Scholar
  125. 125.
    Omenaas E, Bakke P, Elsayed S, Hanoa R, Gulsvik A (1994) Total and specific serum IgE levels in adults: Relationship to sex, age and environmental factors. Clin Exp Allergy 24:530–539.PubMedCrossRefGoogle Scholar
  126. 126.
    Sherrill D, Halonen M, Burrows B (1994) Relationships between total serum IgE, atopy, and smoking: A twenty-year follow up analysis. Allergy Clin Immunol 94:954–962.CrossRefGoogle Scholar
  127. 127.
    Oryszczyn M, Annesi-Maesano I, Campagna D, Sahuquillo J, Huel G, Kauffman H (1999) Head circumference at birth and maternal factors related to cord blood total IgE. Clin Exp Allergy 29:334–341.PubMedCrossRefGoogle Scholar
  128. 128.
    Sapigni T, Biavati P, Simoni M, Viegi G, Baldacci S, Modena P, Pedreschi M, Paoletti P (1998) The Po River Delta respiratory Epidemiological Survey: An analysis of factors related to level of total serum IgE. Eur Respir J 11:278–823.PubMedCrossRefGoogle Scholar
  129. 129.
    Janson C, Chinn S, Jarvis D, Zock J, Toren K, Burney P (2001) Effects of passive smoking on respiratory symptoms, bronchial responsiveness, lung function and total serum IgE in the European Community Respiratory Health Survey: a cross-sectional study. Lancet 358:2103–2109.PubMedCrossRefGoogle Scholar
  130. 130.
    Villar T, Holgate S (1995) IgE, smoking and lung function. Clin Exp Allergy 25:206–209.PubMedCrossRefGoogle Scholar
  131. 131.
    Byron K, Varigos G, Wootton A (1994) IL-4 production is increased in cigarette smokers. Clin Exp Immunol 95:333–336.PubMedGoogle Scholar
  132. 132.
    Jones J, Minty B, Lawler P, Hulands G, Crawley J, Veall N (1980) Increased alveolar epithe lial permeability in cigarette smokers. Lancet 1:66–67.PubMedCrossRefGoogle Scholar
  133. 133.
    Annesi-Maesano I, Oryszczyn M, Raherison C, Kopferschmitt C, Pauli G, Taytard A, Tunon de Lara M, Vervloet D, Charpin D (2004) Increased prevalence of asthma and allied diseases among active adolescent tobacco smokers after controlling for passive smoking exposure. A cause for concern?. Clin Exp Allergy 34:1017–1023.PubMedCrossRefGoogle Scholar
  134. 134.
    Duhme H, Weiland S, Rudolph P, Wienke A, Kramer A, Keil U (1998) Asthma and allergies among children in West and East Germany: a comparison between Munster and Greifswald using the ISAAC phase I protocol. International Study of Asthma and Allergies in Childhood. Eur Respir J 11:840–847.PubMedCrossRefGoogle Scholar
  135. 135.
    Bakke P, Gulsvik A, Eide G (1990) Hayfever, eczema and urticaria in southwest Norway. Lifetime prevalences and association with sex, age, smoking habits, occupational airborne exposures and respiratory symptoms. Allergy 45:515–519.PubMedCrossRefGoogle Scholar
  136. 136.
    Annesi-Maesano I, Oryszczyn M, Neukirch F, Kauffman H (1997) Relationship of upper airway disease to tobaco smoking and allergic markers: a cohort study of men followed up for 5 years. Int Arch Allergy Immunol 114:193–201.PubMedCrossRefGoogle Scholar
  137. 137.
    Montnemery P, Nihlen U, Lofdahl C, Nyberg P, Svensson A (2005) Prevalence of hand eczema in an adult Swedish population and the relationship to risk occupation and smoking. Acta Demato-Venereologica 85:429–432.CrossRefGoogle Scholar
  138. 138.
    Wuthrich B, Schindler C, Medici T, Zellweger J (1996) IgE levels, atopy markers and hay fever in relation to age, sex and smoking staus in a normal adult Swiss population. Int Arch Allergy Immunol 111:396–402.PubMedGoogle Scholar
  139. 139.
    Beer W (1984) Eczema exacerbated by smoking. Contact Dermatitis 10:48–49.PubMedCrossRefGoogle Scholar
  140. 140.
    Schafer T, Dirschedl P, Kunz B, Ring J, Uberla K (1997) Maternal smoking during preg nancy and lactation increases the risk of atopic eczema in the offspring. J Am Acad Dermatol 36:550–556.PubMedCrossRefGoogle Scholar
  141. 141.
    Arshad S, Matthews S, Gant C, et al (1992) Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 339:1493–1497.PubMedCrossRefGoogle Scholar
  142. 142.
    Kulig M, Luck W, Lau S, Niggemann B, Bergmann R, Klettke U, Guggenmoos-Holzmann I, Wahn U (1999_ Effect of pre- and postnatal tobacco smoke exposure on specific sensitization to food and inhalant allergens during the first 3 years of life. Allergy 54:220–228.PubMedCrossRefGoogle Scholar
  143. 143.
    Tariq S, Hakim E, Matthews S, Arshad S (2000) Influence of smoking on asthmatic symp toms and allergen sensitisation in early childhood. Postgrad Med J 76:694–699.PubMedCrossRefGoogle Scholar
  144. 144.
    Ownby D, McCullough J (1988) Passive exposure to cigarette smoke does not increase aller gic sensitization in children. J Allergy Clin Immunol 82:634–638.PubMedCrossRefGoogle Scholar
  145. 145.
    Rantakallio P (1978) Relationship of maternal smoking to morbidity and mortality of the child up to the age of five. Acta Paediatr Scand 67:621–631.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  • Eric Livingston
    • 1
  • Neil C. Thomson
    • 1
  1. 1.Department of Respiratory Medicine, Division of Immunology, Infection and InflammationUniversity of GlasgowGlasgowUK

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