T Cell Responses to the Allergens and Association with Different Wheezing Phenotypes in Children

  • Peter N. Le Souëf
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

In determining relationships between T cell responses to antigens and wheezing in infants and young children, the patterns of development of Th1 and Th2 responses in early life need to be considered as these are closely related to clinical wheezing phenotypes. In addition, factors affecting T cell responses are relevant, as in general, these factors are also associated with wheezing patterns in this age group.

The role of Th2 immune responses in nature is also important. Indeed, the need for these responses at any time of life is still not well understood. Evidence suggests that they are needed for protection from parasitic infections, particularly those due to helminths [1], but this is still not well established [2]. In contrast, much more is known about the role of the immune system in protection from viruses and bacteria. Over the last few years, an individual's Th2 responses have been shown to be directly linked to their Th1 responses. Hence, the role of Th2 responses in nature is likely to be much more complex than is currently understood. Until there is a much better understanding of mechanisms, roles, and development of the various T cell responses, how these relate to wheezing in children may remain relatively obscure.


Respiratory Syncytial Virus Allergy Clin Immunol Respir Crit Environmental Tobacco Smoke Maternal Smoking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer 2009

Authors and Affiliations

  • Peter N. Le Souëf
    • 1
  1. 1.School of Paediatrics and Child HealthUniversity of Western Australia c/o Princess Margaret Hospital for ChildrenPerthAustralia

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