Genetic Markers for Differentiating Aspirin-Hypersensitivity

  • Hae-Sim Park
  • Seung-Hyun Kim
  • Young-Min Ye
  • Gyu-Young Hur
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

The ingestion of acetylsalicylic acid (ASA) can induce allergic reactions such as ASA-intolerant asthma (AIA), ASA-induced acute or chronic urticaria/angioedema (AIAU or AICU), anaphylaxis, and, in rare cases, hypersensitivity pneumonitis [1, 2]. Among these, AIA and AIU are most prevalent. Although the pathogenic mechanism of AIA is not completely understood, a chronic overproduction of cysteinyl leukotrienes (Cys-LTs) derived from cyclooxygenase (COX) inhibition has been consistently found to be associated with the condition [3, 4]. Although recent reports have suggested that an overproduction of Cys-LTs may play a role in AIU development [5, 6], knowledge about the pathogenic mechanism of AIU is limited. Here, we summarize recent data regarding the molecular genetic mechanisms that govern AIA and AIU, with the objective of identifying genetic markers that can be used to differentiate between the two conditions.


Human Leukocyte Antigen Allergy Clin Immunol Chronic Urticaria Human Leukocyte Antigen Allele NSAID Hypersensitivity 


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Copyright information

© Springer 2009

Authors and Affiliations

  • Hae-Sim Park
    • 1
  • Seung-Hyun Kim
    • 1
  • Young-Min Ye
    • 1
  • Gyu-Young Hur
    • 1
  1. 1.Department of Allergy and RheumatologyAjou University School of MedicineSuwonKorea

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