Genetic and Molecular Regulation of β2-Adrenergic Receptors

  • Ian Sayers
  • Ian P. Hall
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

β2-adrenergic receptor agonists are bronchodilators used extensively in the treatment of asthma and other respiratory conditions associated with airflow limitation and obstruction. Both short-acting β2-adrenergic receptor agonists (SABA; e.g., salbutamol) and long-acting β2-adrenergic receptor agonists (LABA; e.g., formoterol) have been developed for acute relief from disease exacerbation or maintenance therapy, respectively.

The pharmacological target of β2-adrenergic receptor agonists is the β2-adrenergic receptor, a G-protein coupled receptor (GPCR) expressed on multiple cell types in the airways and systemically. In this chapter, we focus on the genetic and molecular mechanisms that regulate the expression and activity of this important drug target in the context of respiratory disease.


Allergy Clin Immunol Peak Expiratory Flow Rate Human Airway Smooth Muscle ADRB2 Gene cAMP Response Element Site 
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Copyright information

© Springer 2009

Authors and Affiliations

  • Ian Sayers
    • 1
  • Ian P. Hall
    • 1
  1. 1.Division of Therapeutics and Molecular MedicineUniversity Hospital of NottinghamNottinghamUK

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