Genetics of Pediatric Asthma

  • Naomi Kondo
  • Eiko Matsui
  • Hideo Kaneko
  • Toshiyuki Fukao
  • Takahide Teramoto
  • Zenichiro Kato
  • Hidenori Ohnishi
  • Akane Nishimura
Part of the Allergy Frontiers book series (ALLERGY, volume 1)

Atopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced immunoglobulin E (IgE) responses to environmental antigens. There is much evidence to indicate that asthma and atopy are inheritable diseases. Many survey studies have suggested that certain genes are involved in onset of allergic diseases. Since the pathology of asthma and atopy is not simple, it is suggested that many genes are involved in the onset of asthma and atopy. There are two ways to identify causative genes for certain diseases, namely positional cloning and functional cloning. Using these techniques, many genes such as the β-subunit of the high-affinity IgE receptor (FcεR1 β)-chain gene [1], interleukin-4 receptor α (IL-4Rα) chain-gene [2, 3], IL-4 gene, IL-13 gene [4], (β2 adrenergic receptor (ADR β 2) gene [5] and a disintegrin and metalloproteinase (ADAM33) gene [6] have been cloned as candidate causative genes for asthma and atopy.

In this chapter, we review the genetic predisposition and genes related to the development of asthma and atopy.


Allergic Disease Chain Gene Atopic Asthma Pediatric Asthma Human Leukocyte Antigen Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Naomi Kondo
    • 1
  • Eiko Matsui
    • 1
  • Hideo Kaneko
    • 1
  • Toshiyuki Fukao
    • 1
  • Takahide Teramoto
    • 1
  • Zenichiro Kato
    • 1
  • Hidenori Ohnishi
    • 1
  • Akane Nishimura
    • 1
  1. 1.Department of Pediatrics, Graduate School of MedicineGifu UniversityGifuJapan

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