Exercise-Related Acute Renal Failure
In 1910, Meyer-Betz reported the first published case of acute renal failure with muscular pain, weakness, and dark urine after intense exercise . In 1960, Howenstine reported that this type of acute renal failure was exercise-related myoglobinuria . However, at this time, it was impossible to distinguish hemoglobin from myoglobin, and this type of acute renal failure was considered to be a type of heat stroke. However, in 1970, Jackson  reported that this disorder was exercise-related renal failure and muscle damage, and this publication led to a gradual increase in research interest in myoglobinuric acute renal failure. In 1972, Hamilton et al.  and Knochel , respectively, reported that similar cases were exertional rhabdomyolysis. Matsumoto et al. first reported this disorder in Japan in 1976.