Abstract
Carcinoma of the pancreas occurs with a relatively low incidence of 9 per 100000 in the United States; however, it is the fourth leading cause overall of cancer mortality [1]. Gudjonsson [2] found that of 22319 patients collected from 85 published series from 1949 to 1986, only 0.4% were resected and lived at least 5 years following diagnosis. The current relative 5-year survival rate for the disease is less than 5% [2].
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References
Warshaw AL, Fernandez-Del Castellio C (1992) Pancreatic carcinoma. N Engl J Med 326:455–465
Gudjonsson B (1987) Cancer of the pancreas: 50 years of surgery. Cancer (Phila) 60:2284–2303
Warshaw AL, Swanson RS (1988) Pancreatic cancer in 1988: possibilities and probabilities. Ann Surg 208:541–553
Crist DW, Sitzmann JV, Cameron JL (1987) Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann Surg 206:358–368
Trede M, Schwall G, Saefer H-D (1990) Survival after pancreatoduodenectomy. Ann Surg 211:447–458
Cameron JL, Crist DW, Sitzmann JV, et al (1991) Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer. Am J Surg 161:120–125
Grace PA, Pitt HA, Tompkins RK (1986) Decreased morbidity and mortality after pancreatoduodenectomy. Am J Surg 151:141–149
Pellegrini CA, Heck CF, Raper S, et al (1989) An analysis of the reduced morbidity and mortality rates for pancreaticoduodenectomy. Arch Surg 124:778–781
Cameron JL, Pitt HA, Yeo CJ, et al (1993) One hundred and forty-five consecutive pancreaticoduodenectomies without mortality. Ann Surg 217:430–438
Tepper J, Nardi G, Suit HD (1978) Carcinoma of the pancreas: review of the MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy. Cancer (Phila) 37:1519–1524
Fortner JG (1973) Regional resection of the pancreas: a new surgical approach. Surgery (St Louis) 73:307–320
Fortner JG (1984) Regional pancreatectomy for cancer of the pancreas, ampulla, and other related sites. Tumor staging and results. Ann Surg 199:418–425
Sindelar WF (1989) Clinical experience with regional pancreatectomy for adenocarcinoma of the pancreas. Arch Surg 124:127–132
Johnstone PAS, Sindelar WF, Kinsella TJ (1994) Experimental and clinical studies of intraoperative radiation therapy. Curr Probl Cancer 18:249–292
Kaiser MH, Ellenberg SS (1985) Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120:899–903
Abe M, Yabumoto E, Takahashi M, et al (1974) Intraoperative radiotherapy of gastric cancer. Cancer (Phila) 34:2034–2041
Abe M, Takahashi M, Yabumoto E, et al (1980) Clinical experiences with intraoperative radiotherapy of locally advanced cancers. Cancer (Phila) 45:40–48
Goldson AL (1978) Preliminary clinical experience with intraoperative radiotherapy. J Natl Med Assoc 70:493–495
Abe M, Takahashi M, Yabumoto E, et al (1975) Techniques, indications and results of intraoperative radiotherapy of advanced cancers. Radiology 116:693–702
Wood W, Shipley WU, Gunderson LL, et al (1982) Intraoperative irradiation for unresectable pancreatic carcinoma. Cancer (Phila) 49:1272–1275
Shipley WU, Wood WC, Tepper JC, et al (1984) Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann Surg 200:289–296
Gunderson LL, Martin JK, Kvols LK, et al (1987) Intraoperative and external beam irradiation ± 5-FU for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 13:319–329
Tepper JE, Noyes D, Krall JM, et al (1991) Intraoperative radiation therapy of pancreatic carcinoma. A report of RTOG-8505. In: Abe M, Takahashi M (eds) Intraoperative radiation therapy. Proceedings of the third international symposium on intraoperative radiation therapy. Pergamon, New York, pp 231–233
Sindelar WF, Kinsella T, Tepper J, et al (1983) Experimental and clinical studies with intraoperative radiotherapy. Surg Gynecol Obstet 157:205–219
Manabe T, Shibamoto Y, Ono K, et al (1991) Combined modality treatment for cancer of the pancreas: intraoperative and external radiotherapies. In: Abe M, Takahashi M (eds) Intraoperative radiation therapy. Proceedings of the third international symposium on intraoperative radiation therapy. Pergamon, New York, pp 246–248
Manabe T, Baba N, Ono K, et al (1991) Radical pancreatectomy with intraoperative radiation therapy for pancreatic head cancer. In: Abe M, Takahashi M (eds) Intraoperative radiation therapy. Proceedings of the third international symposium on intraoperative radiation therapy. Pergamon, New York, pp 249–250
Hiraoka T, Watanabe E, Mochinaga M, et al (1984) Intraoperative irradiation combined with radical resection for cancer of the head of the pancreas. World J Surg 8:766–769
Hiraoka T (1990) Extended radical resection of cancer of the pancreas with intraoperative radiotherapy. Ballière’s Clin Gastroenterol 4:985–993
Zerbi A, Fossati V, Parolini D (1994) Intraoperative radiation therapy adjuvant to resection in the treatment of pancreatic cancer. Cancer (Phila) 73:2930–2935
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© 1997 Springer-Verlag Tokyo
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Sindelar, W.F. (1997). Studies of Surgical Resection and Intraoperative Radiotherapy in Carcinoma of the Pancreas. In: Hanyu, F., Takasaki, K. (eds) Pancreatoduodenectomy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68541-8_22
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DOI: https://doi.org/10.1007/978-4-431-68541-8_22
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68543-2
Online ISBN: 978-4-431-68541-8
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