Neurobehavioral Changes Following Cerebral Ischemia and Treatment by a TRH Derivative
Multiple symptoms including reduced spontaneous activity, hemiparesis, and cognitive disturbance are frequently observed in the chronic phase of cerebral vascular diseases in humans. For investigating pathogenesis and drug therapy in the chronic phase of cerebral vascular diseases, it is important to observe the long-term functional consequences in a model of focal cerebral ischemia. Pathological and functional changes including neurological deficits, cognitive disturbances, brain edema, decreased cerebral blood flow and metabolism, and catecholamine levels after focal cerebral ischemia have been well documented in animals. However, most of these changes were observed only in the acute phase and few reports are available concerning the long-term functional consequences of focal cerebral ischemia .
KeywordsMiddle Cerebral Artery Occlusion Focal Cerebral Ischemia Dark Compartment Passive Avoidance Task Left Middle Cerebral Artery
Unable to display preview. Download preview PDF.
- 2.Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) Focal cerebral ischaemia in the rat: I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1: 53–60Google Scholar
- 3.Tamura A, Gotoh O, Sano K (1986) Focal cerebral infarction in the rat: I. Operative technique and physiological monitoring for chronic model. Brain and Nerve (Tokyo) 38: 747–751.Google Scholar
- 9.Yasuhara N, Naito H (1983) Effects of TRH-T and DN-1417 on the central nervous system: An electrophysiological study of arousal reaction and evoked muscular discharges. Int J Neurosci 21: 197–224Google Scholar
- 11.Tamura A, Gotoh O, Sano K, Nagashima T, Matsutani M, Orii H, Graham DI (1986) Focal cerebral infarction in the rat: 2. Neuropathological study and local cerebral blood flow pattern. Brain and Nerve (Tokyo) 38: 859–863Google Scholar