Behavioral and Memory Impairment Following Cerebral Ischemia in Rats

  • Takefumi Sakabe
  • Yoshitoyo Miyauchi
  • Hideto Nakayama
  • Akio Tateishi
  • Takanobu Sano
  • Toshizoh Ishikawa
  • Hiroshi Takeshita


Although the mortality and morbidity of victims of cardiac arrest have been improved with recent progress in the techniques of cardiopulmonary resuscitation and intensive care, many of them remain hospitalized in a vegetative state or die of brain death. Even in those who have regained consciousness within a relatively short period of time after an ischemic insult, neuropsychological and memory impairments may persist either transiently or permanently. Studies on the mechanisms responsible for the development of these conditions may provide a therapeutic window. Thus, there are an increasing number of investigations in animal models that examine the behavioral and memory impairment after cerebral ischemia [1–4]. The present study was undertaken to examine the behavioral and memory changes after forebrain ischemia in rats.


Cerebral Ischemia Memory Impairment Memory Function Mean Arterial Blood Pressure Kainic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Volpe BT, Pulsinelli WA, Tribuna J, Davis HP (1984) Behavioral performance of rats following transient forebrain ischemia. Stroke 15: 558–562PubMedCrossRefGoogle Scholar
  2. 2.
    Davis HP, Tribuna J, Pulsinelli WA, Volpe BT (1986) Reference and working memory of rats following hippocampal damages induced by transient forebrain ischemia. Physiol Behav 37: 387–392PubMedCrossRefGoogle Scholar
  3. 3.
    Davis HP, Baranowski JR, Pulsinelli WA, Volpe BT (1987) Retention of reference memory following ischemic hippocampal damage. Physiol Behav 39: 783–786PubMedCrossRefGoogle Scholar
  4. 4.
    Volpe BT, Waczek B, Davis HP (1988) Modified T-maze training demonstrates dissociated memory loss in rats with ischemic hippocampal injury. Behav Brain Res 27: 259–268PubMedCrossRefGoogle Scholar
  5. 5.
    Smith M-L, Bendek G, Dahlgren N, Rosén I, Wieloch T, Siesjö BK (1984) Models for studying long term recovery following forebrain ischemia in the rats: II. A two-vessel occlusion model. Acta Neurol Scand 69: 385–401Google Scholar
  6. 6.
    Hall CS (1934) Emotional behavior in the rat: I. Defecation and urination as measures of individual differences in emotionality. J Comp Psychol 18: 385–403CrossRefGoogle Scholar
  7. 7.
    Collins RL (1964) Inheritance of avoidance conditioning in mice: A diallel study. Science 143: 1188–1191PubMedCrossRefGoogle Scholar
  8. 8.
    Auer RN, Olsson Y, Siesjö BK (1984) Hypoglycemic brain damage: Correlation of density of brain damage with the EEG isoelectric time. Diabetes 33: 1090–1098Google Scholar
  9. 9.
    Schmidt-Kastner R, Hossmann K-A (1988) Distribution of ischemic neuronal damage in the dorsal hippocampus of rat. Acta Neuropathol 76: 411–421PubMedCrossRefGoogle Scholar
  10. 10.
    Pijnenburg AJJ, Honig WMM, Van Rossum JM (1976) Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity. Eur J Pharmacol 35: 45–58PubMedCrossRefGoogle Scholar
  11. 11.
    Kelly PH, Seviour PW, Iversen SD (1975) Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94: 507–522PubMedCrossRefGoogle Scholar
  12. 12.
    Zervas NT, Hori H, Negora M, Wurtman RJ, Larin F, Lavyne MH (1974) Reduction in brain dopamine following experimental cerebral ischemia. Nature 247: 283–284PubMedCrossRefGoogle Scholar
  13. 13.
    Thierry AM, Tassin JP, Blanc G, Glowinski J (1976) Selective activation of the mesocortical DA system by stress. Nature 263: 242–243PubMedCrossRefGoogle Scholar
  14. 14.
    Jones DL, Mogenson GJ, Wu M (1981) Injections of dopaminergic, cholinergic, serotoninergic and gabaergic drugs into the nucleus accumbens: Effects on locomotor activity in the rat. Neuropharmacology 20: 29–37Google Scholar
  15. 15.
    Bovet D, Bovet-Nitti F, Oliverio A (1969) Genetic aspects of learning and memory in mice. Science 163: 139–149PubMedCrossRefGoogle Scholar
  16. 16.
    Jarrard LE (1978) Selective hippocampal lesions: Differential effects on performance by rats of a spatial task with preoperative versus postopertaive training. J Comp Physiol Psych 92: 1119–1127CrossRefGoogle Scholar
  17. 17.
    Handelmann GE, Olton DS (1981) Spatial memory following damage to hippocampal CA3 pyramidal cells with kainic acid: Impairement and recovery with preoperative training. Brain Res 217: 41–58Google Scholar
  18. 18.
    Smith M-L, Auer RN, Siesjö BK (1984) The density and distribution of ischemic brain injury in the rat following 2–10 min of forebrain ischemia. Acta Neuropathol (Berl) 64: 319–332CrossRefGoogle Scholar
  19. 19.
    Rauca CH, Kammerer E, Matthies H (1980) Choline uptake and permanent memory storage. Pharmacol Biochem Behav 13: 21–25PubMedCrossRefGoogle Scholar
  20. 20.
    Lynch G, Baudry M (1984) The biochemistry of memory: A new and specific hypothesis. Science 224: 1057–1063PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takefumi Sakabe
  • Yoshitoyo Miyauchi
  • Hideto Nakayama
  • Akio Tateishi
  • Takanobu Sano
  • Toshizoh Ishikawa
  • Hiroshi Takeshita
    • 1
  1. 1.Department of Anesthesiology-ResuscitologyYamaguchi University, School of MedicineUbe, 755Japan

Personalised recommendations