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Behavioral and Memory Impairment Following Cerebral Ischemia in Rats

  • Takefumi Sakabe
  • Yoshitoyo Miyauchi
  • Hideto Nakayama
  • Akio Tateishi
  • Takanobu Sano
  • Toshizoh Ishikawa
  • Hiroshi Takeshita

Abstract

Although the mortality and morbidity of victims of cardiac arrest have been improved with recent progress in the techniques of cardiopulmonary resuscitation and intensive care, many of them remain hospitalized in a vegetative state or die of brain death. Even in those who have regained consciousness within a relatively short period of time after an ischemic insult, neuropsychological and memory impairments may persist either transiently or permanently. Studies on the mechanisms responsible for the development of these conditions may provide a therapeutic window. Thus, there are an increasing number of investigations in animal models that examine the behavioral and memory impairment after cerebral ischemia [1–4]. The present study was undertaken to examine the behavioral and memory changes after forebrain ischemia in rats.

Keywords

Cerebral Ischemia Memory Impairment Memory Function Mean Arterial Blood Pressure Kainic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takefumi Sakabe
  • Yoshitoyo Miyauchi
  • Hideto Nakayama
  • Akio Tateishi
  • Takanobu Sano
  • Toshizoh Ishikawa
  • Hiroshi Takeshita
    • 1
  1. 1.Department of Anesthesiology-ResuscitologyYamaguchi University, School of MedicineUbe, 755Japan

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