Protective Effect of Microinjury in Brain Ischemic Damage

  • Koki Shimoji
  • Yoshio Takahata
  • Naoshi Fujiwara
  • Kiichiro Taga
  • Satoru Fukuda


Ischemic brain damage is one of the most serious concerns associated with postresuscitation sequelae and other hemodynamic complications seen in clinical anesthesia and critical medicine. Although numerous preventive measures for the treatment of brain ischemia have been reported in recent years, none of these is promising in clinical practice. This is a report on the induction of certain endogenous protective mechanisms in the artificially injured brain to promote survival of mice subjected to incomplete brain ischemia.


Brain Injury Brain Ischemia Globus Pallidus Ischemic Insult Striate Cortex 
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  1. 1.
    Varon S, Adler R (1981) Trophic and specifying factors directed to neuronal cells. In: Fedoroff S, Hertz L (eds) Advances in Cellular Neurobiology vol 2. Academic, New York, pp 115–163Google Scholar
  2. 2.
    Thoenen H, Edgar D (1985) Neurotrophic factors. Science 229: 238–242PubMedCrossRefGoogle Scholar
  3. 3.
    Nieto-Sampedro M, Needles DL, Cotman CW (1985) A simple, objective method to measure the activity of factors that promote neuronal survival. J Neurosci Methods 15: 37–48PubMedCrossRefGoogle Scholar
  4. 4.
    Takahata Y, Shimoji K (1986) Brain injury improves survival of mice following brain ischemia. Brain Res 381: 368–371PubMedCrossRefGoogle Scholar
  5. 5.
    Shimoji K, Takahata Y, Fujiwara N, Endoh H, Taga K, Ohama E (1987) Effects of pentobarbital and ketamine on brain injury-induced anti-ischemic activity. Brain Res 408: 385–388PubMedCrossRefGoogle Scholar
  6. 6.
    Takeshita H, Okuda Y, Sari A (1972) The effects of ketamine on cerebral circulation and metabolism in man. Anesthesiology 36: 69–75PubMedCrossRefGoogle Scholar
  7. 7.
    Kayama Y, Iwama K (1972) The EEG, evoked potentials, and single unit activity during ketamine anesthesia in cats. Anesthesiology 36: 316–328PubMedCrossRefGoogle Scholar
  8. 8.
    Snell LD, Johnson KM (1985) Antagonism of N-methyl-D-aspartate induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior. J Pharmacol Exp Ther 235: 50–57PubMedGoogle Scholar
  9. 9.
    Olney JW, Price MT, Fuller TA, Labruere J, Samson L, Carpenter M, Mahan K (1986) The anti-excitatoxic effects of certain anesthetics, analgesics and sedativehypnotics. Neurosci Lett 68: 29–34PubMedCrossRefGoogle Scholar
  10. 10.
    Shapiro H-M (1985) Barbiturates in brain ischemia. Br J Anaesth 57: 82–95PubMedCrossRefGoogle Scholar
  11. 11.
    Messick J-M Jr, Milde LN (1987) Brain protection. In: Stoelting RK, Barash PG, Gallagher TJ (eds) Advances in anesthesia vol 4. Year Book Medical Publishers, Chicago. pp 47–87Google Scholar
  12. 12.
    Higashi H, Nishi S (1982) The effect of barbiturates on the GABA receptor of cat primary afferent neurones. J Physiol 332: 299–314PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Koki Shimoji
  • Yoshio Takahata
  • Naoshi Fujiwara
  • Kiichiro Taga
  • Satoru Fukuda
    • 1
  1. 1.Department of AnesthesiologyNiigata University School of MedicineNiigata, 951Japan

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