Protein and Polyamine Metabolism in Reversible Cerebral Ischemia of Gerbils

  • Wulf Paschen
  • Yaxia Xie
  • Gabriele Röhn
  • Joachim Hallmayer
  • Konstantin-Alexander Hossmann


The interruption of blood flow to the brain induces disturbances of brain metabolism [1] which are not immediately reversed after restoration of cerebral blood flow. The timecourses of ischemia-induced disturbances do vary, however, for different biochemical events. The recovery of energy metabolism is a fast process following short-term cerebral ischemia and the content of high energy phosphates is rapidly replenished after the onset of recirculation [2]. Inhibition of protein biosynthesis, in contrast, persisted for hours or even days after ischemia. [3–9]. The consequences of prolonged disturbances in protein biosynthesis are not known; however, it is obvious that persistent inhibition of protein biosynthesis must effect the integrity of the cell as long as the degradation of proteins is not reduced to the same extent as the biosynthesis.


Cerebral Ischemia Protein Biosynthesis Ornithine Decarboxylase Mongolian Gerbil Polyamine Metabolism 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Wulf Paschen
  • Yaxia Xie
  • Gabriele Röhn
  • Joachim Hallmayer
  • Konstantin-Alexander Hossmann
    • 1
  1. 1.Department of Experimental NeurologyMax-Planck-Institute for Neurological ResearchCologne 41Federal Republic of Germany

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