Are Glutamate/Aspartate Antagonists Protective in Cerebral Ischemia?

  • John C. Drummond


The dicarboxylic amino acids glutamate and aspartate are abundant excitatory neurotransmitters in the mammalian nervous system [1]. Glutamate and aspartate and perhaps other endogenous “excitotoxic” substances, eg., quinolinic acid [2,3] have been implicated as contributory or primary causative agents of neuronal injury in several neuropathologic processes including epilepsy [4], Huntington’s disease [5,6], Alzheimer’s disease [7] olivo-pontocerebellar atrophy [8], the degenerative changes associated with hypoglycemia [9], aging, and hypoxic-ischemic injury [10]. The relevance of excitatory amino acids (EAA’s) to hypoxic-ischemic neural injury will be the focus of this presentation. However, an overview of EAA physiology is a necessary back-ground for the discussion.


Middle Cerebral Artery Occlusion Excitatory Amino Acid NMDA Antagonist Quinolinic Acid Cereb Blood Flow 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • John C. Drummond
    • 1
  1. 1.Department of AnesthesiologyUniversity of CaliforniaSan DiegoUSA

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