Advanced Treatment of Prolonged Coma: Selection of Candidates for Deep Brain Stimulation and Clinical Results

  • Takashi Tsubokawa
  • Takamitsu Yamamoto


In an attempt to facilitate recovery from prolonged coma, deep brain stimulation has been applied to the pallidum, the ventroanterior thalamus, the midbrain reticular formation, and the thalamic intralaminar nucleus [1–4]. This approach is based on the anatomical and electrophysiological finding that brain arousal activity might be produced by stimulation of the ascending activating system [5,6]. Deep brain stimulation might also inhibit an active neural process within the brain stem that is involved in the production of coma [7]. However clinical results of deep brain stimulation have been quite variable and long-term follow-up results have not yet been reported [1–4, 8].


Deep Brain Stimulation Vegetative State Neurological Score Wave Versus Chronic Stimulation 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takashi Tsubokawa
  • Takamitsu Yamamoto
    • 1
  1. 1.Department of Neurological Surgery, School of MedicineNihon UniversityItabashi-ku, Tokyo, 173Japan

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