The Role of Calcium Entry Blockers in Brain Ischemia
Drug treatment of cerebral ischemia is still controversial after decades of research, and no treatment appears to be firmly established. This is probably not so surprising when even the mechanisms causing the damage are not firmly established. Many good working hypotheses have been considered during the years, however, and it is exciting that recently a scientifically based connection between many of them appears to have evolved. Disturbances in the calcium homeostasis appears to be present in most cases [1,2], and it was therefore natural to start looking at possible protection against ischemic damage with calcium entry blockers a decade ago. In this paper some of the mechanisms whereby calcium theoretically can be involved in ischemic/hypoxic pathophysiology will be briefly discussed.
KeywordsCerebral Blood Flow Cardiac Arrest Brain Ischemia Neurologic Outcome Mean Arterial Blood Pressure
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