Measurement of Lactic Acid and Amino Acids in the Cerebral Cortex of Head-Injured Patients Using Microdialysis

  • J. Clay Goodman
  • Daniel P. Robertson
  • Shankar P. Gopinath
  • Raj K. Narayan
  • Robert G. Grossman
  • Richard K. SimpsonJr.
  • Claudia S. Robertson


Lactic acidosis and release of excitotoxic amino acids may contribute to secondary brain damage following head injury [1–6]. Microdialysis is one of the most promising new methods for analyzing these neurochemical alterations in the intensive care setting [7–17]. We analyzed the chemical composition of the extracellular space of the brain, which was continuously sampled using microdialysis in 15 brain-injured patients, and correlated these neurochemical data with information regarding intracranial pressure, jugular venous oxygen saturation, clinical events, and patient outcome.


Glasgow Outcome Score Persistent Vegetative State Inhibitory Amino Acid Cerebral Contusion Neurochemical Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • J. Clay Goodman
    • 1
    • 2
  • Daniel P. Robertson
    • 1
  • Shankar P. Gopinath
    • 1
  • Raj K. Narayan
    • 1
  • Robert G. Grossman
    • 1
  • Richard K. SimpsonJr.
    • 1
  • Claudia S. Robertson
    • 1
  1. 1.Departments of NeurosurgeryBaylor College of MedicineHoustonUSA
  2. 2.Departments of PathologyBaylor College of MedicineHoustonUSA

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