Measurement of Excitatory Amino Acid Release in Glioma and Contused Brain Tissue During Intracranial Surgery

  • Tatsuro Kawamata
  • Yoichi Katayama
  • Kosaku Kinoshita
  • Takashi Tsubokawa


Excitatory amino acids (EAAs) may act as causal factors in ischemic or traumatic brain damage, according to the concept of excitotoxicity [1–9]. To understand the pathological role of EAAs in the cell injury process of the central nervous system, we have employed the cerebral microdialysis technique to measure the extracellular concentration of EAAs in our laboratory experiments [4, 6, 10–12]. Recently we have had opportunities to measure EAA levels in brain tumor and contused brain tissue in humans using microdialysis during intracranial surgery. These observations might produce unique opportunities to understand the pathophysiology of human EAA excitotoxicity.


Excitatory Amino Acid Transient Cerebral Ischemia Amino Acid Release Intracranial Surgery Acute Subdural Hematoma 
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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Tatsuro Kawamata
    • 1
  • Yoichi Katayama
    • 1
  • Kosaku Kinoshita
    • 1
  • Takashi Tsubokawa
    • 1
  1. 1.Department of Neurological SurgeryNihon University School of MedicineItabashi-ku, TokyoJapan

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