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Prolonged Stimulation-Induced Afterdischarges of Hippocampal CA1 Pyramidal Cells After Ischemia In Vivo

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Neurochemical Monitoring in the Intensive Care Unit

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Abstract

Transient cerebral ischemia causes selective death of hippocampal CA1 pyramidal cells after a period of 3–5 days [1]. We previously demonstrated that Schaffer collateral/CA1 responses of the rat are potentiated beginning at 6–8 h after transient cerebral ischemia in vivo [2]. The present study examined whether the utilization of N-methyl-d-aspartate (NMDA) receptorcoupled ion channels is increased or not during the period in which postischemic potentiation (PIP) of Schaffer collateral/CAl responses is observed.

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References

  1. Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498

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  2. Miyazaki S, Katayama Y, Furuichi M, Kinoshita K, Kawamata T, Tsubokawa T (1993) Post-ischemic potentiation of Schaffer collateral/CA1 pyramidal cell responses of the rat hippocampus in vivo: involvement of N-methyl-d-aspartate receptors. Brain Res 611: 155–159

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  3. Andine P, Jacobson I, Hagberg H (1988) Calcium uptake evoked by electrical stimulation is enhanced postischemically and precedes delayed neuronal death in CA1 of rat hippocampus: involvement of N-methyl-d-asparate receptors. J Cereb Blood Flow Metab 8: 799–807

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Nihon University School of Medicine, 30-1, Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173, Japan

    Makoto Furuichi, Shuhei Miyazaki, Yoichi Katayama & Takashi Tsubokawa

Authors
  1. Makoto Furuichi
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  2. Shuhei Miyazaki
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  3. Yoichi Katayama
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  4. Takashi Tsubokawa
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Editor information

Editors and Affiliations

  1. Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan

    Takashi Tsubokawa M.D., D.Sc. (Professor and Chairman) (Professor and Chairman)

  2. Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  3. Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA

    Claudia Robertson M.D. (Professor) (Professor)

  4. Department of Neurosurgery, Southern General Hospital, University of Glasgow, Glasgow, Scotland, UK

    Graham Teasdale M.D. (Professor and Chairman) (Professor and Chairman)

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© 1995 Springer-Verlag Tokyo

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Furuichi, M., Miyazaki, S., Katayama, Y., Tsubokawa, T. (1995). Prolonged Stimulation-Induced Afterdischarges of Hippocampal CA1 Pyramidal Cells After Ischemia In Vivo. In: Tsubokawa, T., Marmarou, A., Robertson, C., Teasdale, G. (eds) Neurochemical Monitoring in the Intensive Care Unit. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68522-7_4

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  • DOI: https://doi.org/10.1007/978-4-431-68522-7_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68524-1

  • Online ISBN: 978-4-431-68522-7

  • eBook Packages: Springer Book Archive

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