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Prolonged Stimulation-Induced Afterdischarges of Hippocampal CA1 Pyramidal Cells After Ischemia In Vivo

  • Makoto Furuichi
  • Shuhei Miyazaki
  • Yoichi Katayama
  • Takashi Tsubokawa
Conference paper

Abstract

Transient cerebral ischemia causes selective death of hippocampal CA1 pyramidal cells after a period of 3–5 days [1]. We previously demonstrated that Schaffer collateral/CA1 responses of the rat are potentiated beginning at 6–8 h after transient cerebral ischemia in vivo [2]. The present study examined whether the utilization of N-methyl-d-aspartate (NMDA) receptorcoupled ion channels is increased or not during the period in which postischemic potentiation (PIP) of Schaffer collateral/CAl responses is observed.

Keywords

Pyramidal Cell Sham Control Population Spike Synaptic Response Repetitive Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498PubMedCrossRefGoogle Scholar
  2. 2.
    Miyazaki S, Katayama Y, Furuichi M, Kinoshita K, Kawamata T, Tsubokawa T (1993) Post-ischemic potentiation of Schaffer collateral/CA1 pyramidal cell responses of the rat hippocampus in vivo: involvement of N-methyl-d-aspartate receptors. Brain Res 611: 155–159PubMedCrossRefGoogle Scholar
  3. 3.
    Andine P, Jacobson I, Hagberg H (1988) Calcium uptake evoked by electrical stimulation is enhanced postischemically and precedes delayed neuronal death in CA1 of rat hippocampus: involvement of N-methyl-d-asparate receptors. J Cereb Blood Flow Metab 8: 799–807PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Makoto Furuichi
    • 1
  • Shuhei Miyazaki
    • 1
  • Yoichi Katayama
    • 1
  • Takashi Tsubokawa
    • 1
  1. 1.Department of Neurological SurgeryNihon University School of MedicineItabashi-ku, TokyoJapan

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