Advertisement

Delayed Neuronal Damage Following Focal Ischemic Injury in Stroke-Prone Spontaneously Hypertensive Rats

  • Toshiki Shirotani
  • Katsuji Shima
  • Miwako Iwata
  • Hideyuki Kita
  • Hiroo Chigasaki
Conference paper

Abstract

The striatum is highly vulnerable to ischemia. It also is innervated richly by both the corticostriatal glutamatergic pathway and nigrostriatal dopaminergic projections, which have been shown to interact with each other [1]. Excitatory amino acids, such as glutamate, may contribute to ischemic cell death by causing an intracellular overload of Ca2+ [2]. It has been suggested that dopamine contributes to ischemic cell death by producing oxygen radicals [3] or by potentiating the excitotoxic effects of glutamate [4].

Keywords

Middle Cerebral Artery Corpus Callosum Middle Cerebral Artery Occlusion Produce Oxygen Radical 45Ca Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Cheramy A, Romo R, Godeheu G, Baruch P, Glowinski J (1986) In vivo presynaptic control of dopamine release in the cat caudate nucleus: II. Facilitatory or inhibitory influence of L-glutamate. Neuroscience 19: 1081–1090PubMedCrossRefGoogle Scholar
  2. 2.
    Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7: 369–379PubMedGoogle Scholar
  3. 3.
    Damsma G, Boisvert DP, Mudrick LA, Wenkstern D, Fibiger HC (1990) Effect of transient forebrain ischemia and pargyline on extracellular concentrations of dopamine, serotonin, and their metabolites in the rat striatum as determined by in vivo microdialysis. J Neurochem 54: 801–808PubMedCrossRefGoogle Scholar
  4. 4.
    Globus MY-T, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD (1988) Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neurosci Lett 91: 36–40PubMedCrossRefGoogle Scholar
  5. 5.
    Coyle P (1982) Middle cerebral artery occlusion in the young rat. Stroke 13: 855–859PubMedCrossRefGoogle Scholar
  6. 6.
    Coyle P, Jokelainen PT (1983) Differential outcome to middle cerebral artery occlusion in spontaneously hypertensive stroke-prone rats (SHRSP) and Wistar Kyoto (WKY) rats. Stroke 14: 605–611PubMedCrossRefGoogle Scholar
  7. 7.
    Dienel GA (1984) Regional accumulation of calcium in postischemic rat brain. J Neurochem 43: 913–925PubMedCrossRefGoogle Scholar
  8. 8.
    Shirotani T, Shima K, Iwata M, Kita H, Chigasaki H (1994) Calcium accumulation following middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Cereb Blood Flow Metab 14: 831–836PubMedCrossRefGoogle Scholar
  9. 9.
    Benveniste H, Huttemeier PC, Johansen FF, Diemer NH (1989) Calcium 45 accumulation in the dentate hilus: possible effect of NMDA receptors blockers. In: Hartmann A, Kuschinsky W (eds) Cerebral ischemia and calcium. Springer, Berlin Heidelberg, pp 266–273Google Scholar
  10. 10.
    Nagasawa H, Kogure K (1990) Exo-focal postischemic neuronal death in the rat brain. Brain Res 524: 196–202PubMedCrossRefGoogle Scholar
  11. 11.
    Johnson RL, Koerner JF (1988) Excitatory amino acid neurotransmission. J Med Chem 31: 2057–2066PubMedCrossRefGoogle Scholar
  12. 12.
    McGeorge AJ, Faull RLM (1989) The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29: 503–537PubMedCrossRefGoogle Scholar
  13. 13.
    Hassler R, Haug P, Nitsch C, Kim JS, Paik K (1982) Effect of motor and premotor cortex ablation on concentrations of amino acid, monoamines, and acetylcholine and on the ultrastructure in rat striatum. A confirmation of glutamate as the specific cortico-striatal transmitter. J Neurochem 38: 1087–1098PubMedCrossRefGoogle Scholar
  14. 14.
    Perschak H, Cuenod M (1990) In vivo release of endogenous glutamate and aspartate in the rat striatum during stimulation of the cortex. Neuroscience 35: 283–287PubMedCrossRefGoogle Scholar
  15. 15.
    Leviel V, Gobert A, Guibert B (1990) The glutamate-mediated release of dopamine in the rat striatum: further characterization of the dual excitatoryinhibitory function. Neuroscience 39: 305–312PubMedCrossRefGoogle Scholar
  16. 16.
    Rothman SM, Olney JW (1987) Glutamate and the pathophysiology of hypoxicischemic brain damage. Ann Neurol 19: 105–111CrossRefGoogle Scholar
  17. 17.
    Choi DW, Maulucci-Gedde M, Kriegstein AR (1987) Glutamate neurotoxicity in cortical cell curture. J Neurosci 7: 357–368PubMedGoogle Scholar
  18. 18.
    Nordborg C, Sokrab TEO, Johansson BB (1991) The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction. Acta Neuropathol (Bed) 82: 118–126CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Toshiki Shirotani
    • 1
  • Katsuji Shima
    • 1
  • Miwako Iwata
    • 1
  • Hideyuki Kita
    • 1
  • Hiroo Chigasaki
    • 1
  1. 1.Department of NeurosurgeryNational Defense Medical CollegeTokorozawa, SaitamaJapan

Personalised recommendations