Delayed Neuronal Damage Following Focal Ischemic Injury in Stroke-Prone Spontaneously Hypertensive Rats

  • Toshiki Shirotani
  • Katsuji Shima
  • Miwako Iwata
  • Hideyuki Kita
  • Hiroo Chigasaki
Conference paper


The striatum is highly vulnerable to ischemia. It also is innervated richly by both the corticostriatal glutamatergic pathway and nigrostriatal dopaminergic projections, which have been shown to interact with each other [1]. Excitatory amino acids, such as glutamate, may contribute to ischemic cell death by causing an intracellular overload of Ca2+ [2]. It has been suggested that dopamine contributes to ischemic cell death by producing oxygen radicals [3] or by potentiating the excitotoxic effects of glutamate [4].


Middle Cerebral Artery Corpus Callosum Middle Cerebral Artery Occlusion Produce Oxygen Radical 45Ca Accumulation 
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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Toshiki Shirotani
    • 1
  • Katsuji Shima
    • 1
  • Miwako Iwata
    • 1
  • Hideyuki Kita
    • 1
  • Hiroo Chigasaki
    • 1
  1. 1.Department of NeurosurgeryNational Defense Medical CollegeTokorozawa, SaitamaJapan

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